The Calgary Guide to Understanding Disease @TheCalgaryGuide
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diagnosis signs symptoms complications allergy hypersensitivityreaction manifestations msk adhesivecapsulitis ankylosingspondylitis benign bph c5c9deficiency cascade centralretinalartery comparison complement crao degenerative diabetes
Anaphylaxis: Pathogenesis Anaphylaxis is a Type 1 hypersensitivity reaction While the primary mechanism of anaphylaxis is mast cell
Anaphylaxis is ... production of inflammatory ... Recruitment of inflammatory ... #pathophysiology ... #immunology
Inflammatory Cascade: Pathogenesis and Clinical Findings Continued Innate Immunity • Phagocytosis: (main mechanism) neutrophils and macrophages engulf
Inflammatory Cascade ... destruction), promote inflammation ... #Cascade #Inflammation ... #pathophysiology ... #immunology
Anaphylaxis: Signs and Symptoms Anaphylaxis: when any egg of three conditions is met: 1. Acute onset of skin/mucosal
Anaphylaxis: Signs ... and Symptoms Anaphylaxis ... Angioedema #Anaphylaxis ... #pathophysiology ... #immunology #diagnosis
X-Linked Agammaglobulinemia: Pathogenesis and clinical findings The epidemiology of this disease is 1/340,000 births and roughly double
X-Linked Agammaglobulinemia ... common antigens #Agammaglobulinemia ... #XLinked #pathophysiology ... #immunology
Type I Hypersensitivity: Pathogenesis and clinical findings Definition: Production of lgE Antibodies that bind to harmless allergens
release the pro-inflammatory ... secretion • Inflammatory ... conjunctivitis • Anaphylaxis ... HypersensitivityReaction #Allergy #Immunology ... #pathophysiology
Anaphylaxis: Treatments (Acute) Additional Info: • IV steroids may be considered for prevention of late phase reactions.
Anaphylaxis: Treatments ... Ventolin inhaler #Anaphylaxis ... Treatments #Management #pathophysiology ... #immunology
Type IV Hypersensitivity: Pathogenesis and clinical findings Definition: Unique because it is entirely T-Cell mediated; exposure to
cells or CTLs -> Inflammation ... HypersensitivityReaction #Allergy #Immunology ... #pathophysiology
Distinguishing between Inflammatory and Degenerative joint disease Inflammatory Joint Disease • Swelling stimulates joint nociceptors -> Pain
Distinguishing between Inflammatory ... joint disease Inflammatory ... Swollen Joints • Inflammation ... mild synovial inflammation ... JointPain #Diagnosis #pathophysiology
Lupus (SLE): Mucocutaneous Manifestations • Langerhan cells and keratinocytes release cytokines -> localized inflammatory response ->
cytokines -> localized inflammatory ... scaling that extend inflammation ... -> Incr local inflammation ... follicles due to inflammation ... Manifestations #pathophysiology
Lower Urinary Tract Infections: Complications - Infection damages the urinary tract epithelium causing fibroblast proliferation and
Bacterial toxins and inflammation ... in a systemic inflammatory ... UrinaryTractInfection #LUTI #Pathophysiology
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