The Calgary Guide to Understanding Disease @TheCalgaryGuide
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Anaphylaxis: Signs and Symptoms
Anaphylaxis: when any egg of three conditions is met:
1. Acute onset of skin/mucosal
Acute onset of skin ... symptoms in the acute ... Signs / Symptoms / Complications ... pathophysiology #immunology ... #diagnosis #signs
Acute Rheumatic Fever: Pathogenesis and Clinical Findings

Delayed autoimmune reaction
-> Molecular mimicry
-> GAS antigen cross-reacts with host
->
Acute Rheumatic ... Tissue injury and inflammation ... , Carditis #Acute ... pathophysiology #diagnosis ... signs #symptoms #complications
Acute Otitis Media: Complications
Infection and inflammation of the middle ear
 - Prolonged obstruction of e. tube
Acute Otitis Media ... : Complications ... Infection and inflammation ... Balance Problems #Acute ... symptoms #signs #diagnosis
Systemic Lupus Erythematosus: Gastrointestinal Manifestations
 - Thrombosis of vessels in the pancreas, Vasculitis -> Acute Pancreatitis
Vasculitis -> Acute ... Gastrointestinal #Complications ... signs #symptoms #diagnosis
Type I Hypersensitivity: Pathogenesis and clinical findings
Definition: Production of lgE Antibodies that bind to harmless allergens
cells recruited Complications ... : • Acute Asthma ... HypersensitivityReaction #Allergy #Immunology
Acute Otitis Media: Pathogenesis and Clinical Findings (in Children)
Upper Respiratory Tract Infection: 
 - Bacterial: Streptococcus
Acute Otitis Media ... bacterial. => Inflammation ... resolve by 72 hours Complications ... pathophysiology #diagnosis
Lupus (SLE): Mucocutaneous Manifestations

 • Langerhan cells and keratinocytes release cytokines -> localized inflammatory response ->
scaling that extend inflammation ... -> Incr local inflammation ... follicles due to inflammation ... pathophysiology #diagnosis ... signs #symptoms #complications
Retinoblastoma: Pathogenesis and clinical findings
 • Sporadic mutation -> One allele of RB1 tumor suppressor gene
Signs / Symptoms / Complications ... reflex) • Orbital inflammation ... ophthalmology #diagnosis
Mastoiditis: Pathogenesis and clinical findings

Acute or Chronic Otitis Media -> 
Stage 1: Hyperemeia of the mastoid
clinical findings Acute ... mastoid air cells (inflammation ... mucosa leads to inflammation ... mastoid air cells (inflammation ... signs #symptoms #diagnosis
Benign Prostatic Hyperplasia: Pathogenesis and Clinical Findings

Hormonal alterations (result of aging process)
    ->
Benign Prostatic Hyperplasia ... FGF-related proteins) Inflammation ... Hydronephrosis, Acute ... Benign #Prostatic #Hyperplasia ... Signs #Symptoms #Diagnosis