The Calgary Guide to Understanding Disease @TheCalgaryGuide
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diagnosis pathophysiology signs complications sle erythematosus extraarticular msk ra rheumatoidarthritis systemic ankylosingspondylitis benign bph comparison degenerative gastrointestinal inflammatory jointdisease jointpain
Lupus (SLE): Mucocutaneous Manifestations • Langerhan cells and keratinocytes release cytokines -> localized inflammatory response ->
Lupus (SLE): Mucocutaneous ... Manifestations ... Subacute cutaneous lupus ... Mucocutaneous #Manifestations ... diagnosis #signs #symptoms
Systemic Lupus Erythematosus: Gastrointestinal Manifestations - Thrombosis of vessels in the pancreas, Vasculitis -> Acute Pancreatitis
Systemic Lupus Erythematosus ... Gastrointestinal Manifestations ... #Systemic #Lupus ... pathophysiology #signs #symptoms
Systemic Lupus Erythematosus (SLE): Musculoskeletal Manifestations • Immune Complex Deposition - Arthralgia, Arthritis
Systemic Lupus Erythematosus ... Musculoskeletal Manifestations ... #Systemic #Lupus ... pathophysiology #signs #symptoms
Rheumatoid arthritis (RA): Extra-articular manifestations Skin: • Inflammation of skin (esp. over areas of stress) forms
Extra-articular manifestations ... Skin: • Inflammation ... Eyes: • Globe inflammation ... on CXR • RA inflammation ... pathophysiology #signs #symptoms
Benign Prostatic Hyperplasia: Pathogenesis and Clinical Findings Hormonal alterations (result of aging process) ->
Benign Prostatic Hyperplasia ... FGF-related proteins) Inflammation ... granulocytes) -> Prostate Inflammation ... Benign #Prostatic #Hyperplasia ... Urology #Signs #Symptoms
Distinguishing between Inflammatory and Degenerative joint disease Inflammatory Joint Disease • Swelling stimulates joint nociceptors -> Pain
Swollen Joints • Inflammation ... Rheumatoid arthritis, Lupus ... Extra-articular manifestations ... mild synovial inflammation
Rheumatoid arthritis (RA): Pathogenesis and Joint diseases features • RA affects 1% of population, women >
Extra-articular manifestations ... etc • Systemic inflammation ... pathophysiology #signs #symptoms
Ankylosing Spondylitis: Extra-articular Manifestations • Ocular - Inflammation of the iris, the anterior part of the
Extra-articular Manifestations ... • Ocular - Inflammation ... • Cardiac - Inflammation ... Extraarticular #Manifestations ... diagnosis #signs #symptoms
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