The Calgary Guide to Understanding Disease @TheCalgaryGuide
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Account created for The Calgary Guide to Understanding Disease - Linking pathophysiology to clinical presentation - http://calgaryguide.ucalgary.ca/
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symptoms complications manifestations msk adhesivecapsulitis ankylosingspondylitis benign bph centralretinalartery comparison crao degenerative extraarticular frozenshoulder hyperplasia incontinence jointdisease jointpain mastoiditis mixed
Lupus (SLE): Mucocutaneous Manifestations • Langerhan cells and keratinocytes release cytokines -> localized inflammatory response ->
Lupus (SLE): Mucocutaneous ... cytokines -> localized inflammatory ... Subacute cutaneous lupus ... Manifestations #pathophysiology ... #diagnosis #signs
Adhesive Capsulitis (Frozen Shoulder) - Pathogenesis and Clinical Findings • Primary (Idiopathic): Unknown etiology, but associated
as post-inflammatory ... FrozenShoulder #pathophysiology ... #diagnosis #symptoms ... #signs #stages ... #staging #msk
Distinguishing between Inflammatory and Degenerative joint disease Inflammatory Joint Disease • Swelling stimulates joint nociceptors -> Pain
Swollen Joints • Inflammation ... Rheumatoid arthritis, Lupus ... mild synovial inflammation ... JointDisease #JointPain #Diagnosis ... #pathophysiology
Mastoiditis: Pathogenesis and clinical findings Acute or Chronic Otitis Media -> Stage 1: Hyperemeia of the mastoid
mucosa leads to inflammation ... : Extension of inflammatory ... #Mastoiditis #pathophysiology ... #signs #symptoms ... #diagnosis #otology
Rheumatoid arthritis (RA): Pathogenesis and Joint diseases features • RA affects 1% of population, women >
• Rate of inflammatory ... etc • Systemic inflammation ... RheumatoidArthritis #RA #pathophysiology ... #signs #symptoms ... #diagnosis
Benign Prostatic Hyperplasia: Pathogenesis and Clinical Findings Hormonal alterations (result of aging process) ->
alterations (result of aging ... activation of inflammatory ... Hyperplasia #Prostate #Pathophysiology ... #Urology #Signs ... #Symptoms #Diagnosis
Central Retinal Artery Occlusion: Pathogenesis and clinical findings • Inflammatory Disease: (i.e. GCA, SLE, GPA) ->
clinical findings • Inflammatory ... viscosity and inflammation ... Occlusion #CRAO #pathophysiology ... ophthalmology #diagnosis ... #signs #symptoms
Mixed Urinary Incontinence: Pathogenesis and Clinical Findings Urgency Urinary Incontinence (UUI) -> Urinary leakage preceded by a
(neurogenic), inflammation ... Incontinence #Mixed #Pathophysiology ... #Signs #Symptoms ... #Urology #Diagnosis
Psoriatic Arthritis: Complications • Ocular - Inflammation of middle layer of the eye (the uvea, which
• Ocular - Inflammation ... Valvular disease - Inflammatory ... WBCs activity -> inflammation ... PsoriaticArthritis #pathophysiology ... #diagnosis #signs
Ankylosing Spondylitis: Extra-articular Manifestations • Ocular - Inflammation of the iris, the anterior part of the
photophobia • GI - Inflammatory ... endoscopy (Not Inflammatory ... • Cardiac - Inflammation ... Complications #pathophysiology ... #diagnosis #signs
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