The Calgary Guide to Understanding Disease @TheCalgaryGuide
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pathophysiology diagnosis signs manifestations urology ankylosingspondylitis benign bph c5c9deficiency extraarticular hyperplasia lupus mixed mucocutaneous prostate prostatic psoriaticarthritis sle urinary
Inflammatory Cascade: Pathogenesis and Clinical Findings Continued Innate Immunity • Phagocytosis: (main mechanism) neutrophils and macrophages engulf
Inflammatory Cascade ... dead tissue • Complement ... activation of complement ... #Cascade #Inflammation ... pathophysiology #immunology
C5-C9 Deficiency - Pathogenesis and Clinical Findings Note: • Risk of invasive meningococcal disease is 1000-10000x higher
is rare Normal complement ... response: The complement ... cascade -> MAC ... • Inflammation ... pathophysiology #immunology
Mixed Urinary Incontinence: Pathogenesis and Clinical Findings Urgency Urinary Incontinence (UUI) -> Urinary leakage preceded by a
Mixed Urinary Incontinence ... Urgency Urinary Incontinence ... (neurogenic), inflammation ... Incr PVR if a complication ... Pathophysiology #Signs #Symptoms
Lupus (SLE): Mucocutaneous Manifestations • Langerhan cells and keratinocytes release cytokines -> localized inflammatory response ->
cytokines -> localized inflammatory ... scaling that extend inflammation ... -> Incr local inflammation ... diagnosis #signs #symptoms ... #complications
Ankylosing Spondylitis: Extra-articular Manifestations • Ocular - Inflammation of the iris, the anterior part of the
photophobia • GI - Inflammatory ... endoscopy (Not Inflammatory ... Bladder and bowel incontinence ... Manifestations #Complications ... diagnosis #signs #symptoms
Psoriatic Arthritis: Complications • Ocular - Inflammation of middle layer of the eye (the uvea, which
Psoriatic Arthritis: Complications ... • Ocular - Inflammation ... Valvular disease - Inflammatory ... diagnosis #signs #symptoms ... #Complications
Benign Prostatic Hyperplasia: Pathogenesis and Clinical Findings Hormonal alterations (result of aging process) ->
FGF-related proteins) Inflammation ... granulocytes) -> Prostate Inflammation ... activation of inflammatory ... Urgency, nocturia, incontinence ... Urology #Signs #Symptoms
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