The Calgary Guide to Understanding Disease @TheCalgaryGuide
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Account created for The Calgary Guide to Understanding Disease - Linking pathophysiology to clinical presentation - http://calgaryguide.ucalgary.ca/
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diagnosis pathophysiology symptoms complications sle adhesivecapsulitis ankylosingspondylitis comparison degenerative erythematosus extraarticular frozenshoulder jointdisease jointpain mucocutaneous musculoskeletal ra rheumatoidarthritis stages staging
Lupus (SLE): Mucocutaneous Manifestations • Langerhan cells and keratinocytes release cytokines -> localized inflammatory response ->
Lupus (SLE): Mucocutaneous ... Manifestations ... cytokines -> localized inflammatory ... Mucocutaneous #Manifestations ... pathophysiology #diagnosis #signs
Systemic Lupus Erythematosus (SLE): Musculoskeletal Manifestations • Immune Complex Deposition - Arthralgia, Arthritis
Systemic Lupus Erythematosus ... Musculoskeletal Manifestations ... #Systemic #Lupus ... Erythematosus #SLE #MSK ... pathophysiology #signs
Distinguishing between Inflammatory and Degenerative joint disease Inflammatory Joint Disease • Swelling stimulates joint nociceptors -> Pain
Swollen Joints • Inflammation ... Rheumatoid arthritis, Lupus ... Extra-articular manifestations ... mild synovial inflammation ... Comparison #Versus #MSK
Adhesive Capsulitis (Frozen Shoulder) - Pathogenesis and Clinical Findings • Primary (Idiopathic): Unknown etiology, but associated
shoulder joint inflammation ... as post-inflammatory ... shoulder joint inflammation ... diagnosis #symptoms #signs ... stages #staging #msk
Rheumatoid arthritis (RA): Pathogenesis and Joint diseases features • RA affects 1% of population, women >
Extra-articular manifestations ... • Rate of inflammatory ... etc • Systemic inflammation ... Extra-articular signs ... pathophysiology #signs
Ankylosing Spondylitis: Extra-articular Manifestations • Ocular - Inflammation of the iris, the anterior part of the
Extra-articular Manifestations ... photophobia • GI - Inflammatory ... endoscopy (Not Inflammatory ... Extraarticular #Manifestations ... pathophysiology #diagnosis #signs
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