The Calgary Guide to Understanding Disease @TheCalgaryGuide
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Account created for The Calgary Guide to Understanding Disease - Linking pathophysiology to clinical presentation - http://calgaryguide.ucalgary.ca/
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diagnosis signs complications extraarticular msk ra rheumatoidarthritis acute adhesivecapsulitis ankylosingspondylitis benign bph cascade centralretinalartery comparison degenerative frozenshoulder hyperplasia jointdisease jointpain
Inflammatory Cascade: Pathogenesis and Clinical Findings Continued Innate Immunity • Phagocytosis: (main mechanism) neutrophils and macrophages engulf
Inflammatory Cascade ... destruction), promote inflammation ... #Cascade #Inflammation ... #pathophysiology ... #immunology
Central Retinal Artery Occlusion: Pathogenesis and clinical findings • Inflammatory Disease: (i.e. GCA, SLE, GPA) ->
clinical findings • Inflammatory ... viscosity and inflammation ... due to upstream CRAO ... #pathophysiology ... diagnosis #signs #symptoms
Lupus (SLE): Mucocutaneous Manifestations • Langerhan cells and keratinocytes release cytokines -> localized inflammatory response ->
Mucocutaneous Manifestations ... cytokines -> localized inflammatory ... Mucocutaneous #Manifestations ... #pathophysiology ... diagnosis #signs #symptoms
Acute Otitis Media: Complications Infection and inflammation of the middle ear - Prolonged obstruction of e. tube
Infection and inflammation ... severe Signs/Symptoms ... Problems #Acute #OtitisMedia ... Complications #pathophysiology ... #symptoms #signs
Rheumatoid arthritis (RA): Extra-articular manifestations Skin: • Inflammation of skin (esp. over areas of stress) forms
Extra-articular manifestations ... Skin: • Inflammation ... Eyes: • Globe inflammation ... RheumatoidArthritis #RA #pathophysiology ... #signs #symptoms
Acute Otitis Media: Pathogenesis and Clinical Findings (in Children) Upper Respiratory Tract Infection: - Bacterial: Streptococcus
. => Inflammation ... mechanisms) #OtitisMedia ... #pathophysiology ... #diagnosis #symptoms
Distinguishing between Inflammatory and Degenerative joint disease Inflammatory Joint Disease • Swelling stimulates joint nociceptors -> Pain
joint disease Inflammatory ... Swollen Joints • Inflammation ... Extra-articular manifestations ... mild synovial inflammation ... JointPain #Diagnosis #pathophysiology
Polyarteritis Nodosa (PAN): Pathogenesis and Clinical Findings Medical Comorbidities Malignancies (most commonly hairy-cell leukemia) Immunogenetic Predisposition: patient is
activating cellular inflammatory ... swelling - GI Manifestations ... PolyarteritisNodosa #Pathophysiology ... Diagnosis #Signs #Symptoms
Mastoiditis: Pathogenesis and clinical findings Acute or Chronic Otitis Media -> Stage 1: Hyperemeia of the mastoid
mastoid air cells (inflammation ... mucosa leads to inflammation ... : Extension of inflammatory ... #Mastoiditis #pathophysiology ... #signs #symptoms
Ankylosing Spondylitis: Extra-articular Manifestations • Ocular - Inflammation of the iris, the anterior part of the
Extra-articular Manifestations ... photophobia • GI - Inflammatory ... endoscopy (Not Inflammatory ... Complications #pathophysiology ... diagnosis #signs #symptoms
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