The Calgary Guide to Understanding Disease @TheCalgaryGuide
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Account created for The Calgary Guide to Understanding Disease - Linking pathophysiology to clinical presentation - http://calgaryguide.ucalgary.ca/
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diagnosis complications ophthalmology vasculitis acute cellulitis extraarticular manifestations psoriaticarthritis ra rheumatoidarthritis urology adhesivecapsulitis agammaglobulinemia anaphylaxis ankylosingspondylitis arteritis arthropathy benign bph
Inflammatory Cascade: Pathogenesis and Clinical Findings Continued Innate Immunity • Phagocytosis: (main mechanism) neutrophils and macrophages engulf
Inflammatory Cascade ... destruction), promote inflammation ... #Cascade #Inflammation ... #pathophysiology ... #immunology
Acute Otitis Media: Complications Infection and inflammation of the middle ear - Prolonged obstruction of e. tube
Infection and inflammation ... /Symptoms/Complications ... Problems #Acute #OtitisMedia ... Complications #pathophysiology ... #symptoms #signs
Anaphylaxis: Signs and Symptoms Anaphylaxis: when any egg of three conditions is met: 1. Acute onset of skin/mucosal
Anaphylaxis: Signs ... Signs / Symptoms ... #Anaphylaxis #pathophysiology ... #immunology #diagnosis ... #signs #symptoms
Acute Otitis Media: Pathogenesis and Clinical Findings (in Children) Upper Respiratory Tract Infection: - Bacterial: Streptococcus
. => Inflammation ... mechanisms) #OtitisMedia ... #pathophysiology ... #diagnosis #symptoms ... #signs #peds #pediatrics
Giant Cell (Temporal) Arteritis: Pathogenesis and investigations Risk Factors: - Unclear environmental triggers (may be viral, not
mutation) that alter inflammatory ... yrs old; F>M Signs ... /Symptoms: - Fever ... Temporal #Arteritis #Pathophysiology ... #Diagnosis #Signs
Lupus (SLE): Mucocutaneous Manifestations • Langerhan cells and keratinocytes release cytokines -> localized inflammatory response ->
cytokines -> localized inflammatory ... -> Incr local inflammation ... Manifestations #pathophysiology ... #diagnosis #signs ... #symptoms #complications
Retinoblastoma: Pathogenesis and clinical findings • Sporadic mutation -> One allele of RB1 tumor suppressor gene
Retinoblastoma Signs ... / Symptoms / Complications ... reflex) • Orbital inflammation ... Retinoblastoma #pathophysiology ... #symptoms
Reactive Arthritis • Inflammation of joints (commonly large joints) - Asymmetric Oligoarthritis: Joint
Arthritis • Inflammation ... Effusions • Inflammation ... ReactiveArthritis #pathophysiology ... #diagnosis #signs ... #symptoms
Orbital Cellulitis: Pathogenesis and Clinical Findings Definitions: a. Chemosis: Edema of the bulbar conjunctiva b. Panopthalmitis: inflammation of all
Panopthalmitis: inflammation ... Endopthalmitis: inflammation ... Orbital #Cellulitis #pathophysiology ... ophthalmology #diagnosis #signs ... #symptoms
Rheumatoid arthritis (RA): Extra-articular manifestations Skin: • Inflammation of skin (esp. over areas of stress) forms
manifestations Skin: • Inflammation ... Eyes: • Globe inflammation ... on CXR • RA inflammation ... RheumatoidArthritis #RA #pathophysiology ... #signs #symptoms
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