The Calgary Guide to Understanding Disease @TheCalgaryGuide
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Account created for The Calgary Guide to Understanding Disease - Linking pathophysiology to clinical presentation - http://calgaryguide.ucalgary.ca/
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Graves’ Disease: Pathogenesis and Clinical Findings
B & T lymphocyte mediated autoimmunity attack TSH receptor -> Continuous
Graves’ Disease: ... the etiology Signs ... pathophysiology #endocin ... #endocrinology ... #symptoms #signs
Growth Hormone Excess - Pathogenesis and clinical findings
 • Acromegaly and gigantism share the same pathophysiology
• Other rare causes ... Acne • Coarse features ... Overproduction #diagnosis #signs ... #symptoms #endocrinology
Trendelenburg Gait: Pathogenesis and clinical findings

Skeletal Pathology of the Hip
 • Arthritis
 • Congenital hip dysplasia
Greater Trochanter Fracture ... pathophysiology #causes ... #symptoms #signs ... #diagnosis #msk
Adhesive Capsulitis (Frozen Shoulder) - Pathogenesis and Clinical Findings

 • Primary (Idiopathic): Unknown etiology, but associated
, humeral head fracture ... a stroke that caused ... diagnosis #symptoms #signs ... stages #staging #msk
Paget’s Disease: Complications
Abnormal Osteoclasts cause excessive bone turnover -> Incr bone resorption, Incr (abnormal) bone formation

MSK
Abnormal Osteoclasts cause ... bone formation MSK ... -> Pathologic fractures ... Skull expansion causes ... pathophysiology #diagnosis #signs
Fracture Healing (and disruptors of this process)
Inflammatory Stage (0-7d)
 • Fracture disrupts local blood vessels ->
Fracture Healing ... Stage (0-7d) • Fracture ... - Metabolic / Endocrine ... Fluoroquinolones - Causes ... #Orthopedics #msk
Anorexia Nervosa: Complications
CARDIAC ABNORMALITIES
 - Functional: Low BP, Sinus bradycardia, prolonged QT interval
 - Structural: Reduced
thrombocytopenia ENDOCRINE ... increased risk of fracture ... warmth) GENERAL FEATURES ... highest mortality rates ... pathophysiology #diagnosis #signs