The Calgary Guide to Understanding Disease @TheCalgaryGuide
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Type I Hypersensitivity: Pathogenesis and clinical findings
Definition: Production of lgE Antibodies that bind to harmless allergens
clinical findings Definition ... degranulation, leading ... to an allergic ... #TypeI #Type1 #HypersensitivityReaction ... #pathophysiology
Type IV Hypersensitivity: Pathogenesis and clinical findings
Definition: Unique because it is entirely T-Cell mediated; exposure to
clinical findings Definition ... Allergic reaction ... TypeIV #Type4 #HypersensitivityReaction ... #Allergy #Immunology ... #pathophysiology
Type III Hypersensitivity: Pathogenesis and clinical findings
Definition: Small antigen-antibody complexes (produced from normal immune response to
clinical findings Definition ... TypeIII #Type3 #HypersensitivityReaction ... #Allergy #Immunology ... #pathophysiology
Hypersensitivity: Summary
Type I Hypersensitivity:
 • Immunological Mediator: lgE
 • Immunological Target: Allergen Molecules
 • Ex: Antibiotic
Immunological Target: Allergen ... fever, Urticaria, Allergic ... #Allergic #Reactions ... #Types #Classification ... #Diagnosis #Definitions
Hypersensitivity: Definitions
 • Type I - Production of lgE Abs that bind to harmless allergens and
Hypersensitivity: Definitions ... degranulation, leading ... immune reaction, leading ... #Types #Classification ... #Diagnosis #Definitions
Low Ankle Sprain: Pathomechanics and Clinical Findings

Grading Ligament Sprains
l: Minimal ligament disruption, mild swelling & tenderness,
Clinical Findings Grading ... LowAnkleSprain #Sports #MSK ... #orthopedics #Grading ... #Grades #Diagnosis ... #pathophysiology
Type II Hypersensitivity: Pathogenesis and clinical findings
Definition: When antigens bind to the body's cell surfaces, forming
clinical findings Definition ... #Type2 #Type2 #HypersensitivityReaction ... #Allergy #Immunology ... #pathophysiology
Patellofemoral Syndrome - Pathogenesis and clinical findings
 • Anterior Knee Pain with possible symptoms of 'catching'
pain • Palpable grinding ... Patellofemoral #Syndrome #pathophysiology ... #diagnosis #signs ... #symptoms #msk
Classification of Pelvic Ring Fractures: Mechanisms, Clinical Features and Complications
 • Anterior Posterior Compression (APC) -
Classification of ... #Grades #Grading ... #Orthopedics #MSK ... #diagnosis #complications ... #pathophysiology
Posterior Cruciate Ligament (PCL) Injury: Pathogenesis and Clinical Findings
Classification of PCL Iniuries
 • Partial: Translation <
Clinical Findings Classification ... #PCL #Injury #MSK ... #Sports #pathophysiology ... #classification ... #diagnosis