The Calgary Guide to Understanding Disease @TheCalgaryGuide
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Acute Spinal Cord Injuries: Pathogenesis and clinical findings
 • Anterior Cord Syndrome -> Anterior spinal artery
spinal artery injury ... function below injury ... Syndromes #diagnosis #pathophysiology ... #signs #symptoms ... #msk #orthopedics
Acute Closed Angle Glaucoma: Pathogenesis and Clinical Findings
OPHTHALMIC EMERGENCY: Early detection is essential, but most patients
lights are a key symptom ... • Significant cause ... most frequent cause ... #pathophysiology ... #ophthalmology
Retinoblastoma: Pathogenesis and clinical findings
 • Sporadic mutation -> One allele of RB1 tumor suppressor gene
Retinoblastoma Signs / Symptoms ... • Secondary glaucoma ... Retinoblastoma #pathophysiology ... #ophthalmology ... diagnosis #signs #symptoms
Meralgia paresthetica: Pathogenesis and Clinical Findings
Compression/injury of Lateral Femoral Cutaneous Nerve (LFCN) -> Meralgia paresthetica
 •
Findings Compression/injury ... paresthetica • Symptoms ... 3-6 months of symptom ... MeralgiaParesthetica #MSK ... #pathophysiology
Femoral Head Fracture: Pathogenesis and clinical findings
 • Posterior hip dislocation -> Impaction force from femoral
Avulsion or shearing injury ... lateral hip Signs/Symptoms ... FemoralHead #Fractures #msk ... #diagnosis #pathophysiology ... #signs #symptoms
Childhood Immunization Schedule: Why we immunize
 • Diphtheria Toxin -> URT inflammation causes pseudomembrane with hardened
URT inflammation causes ... metabolites induce injury ... hemorrhagic rash; symptoms ... non-specific viral symptoms ... peds #pediatrics #pathophysiology
Systemic Lupus Erythematosus (SLE): Musculoskeletal Manifestations

 • Immune Complex Deposition
    - Arthralgia, Arthritis
Myopathy (Also caused ... Erythematosus #SLE #MSK ... Complications #pathophysiology ... #signs #symptoms
Cauda Equina Syndrome
Causes:
 • Large lumbar degenerative disc herniation (central)
 • Severe lumbar spondylosis
 • Neoplasm
Equina Syndrome Causes ... spine Signs / Symptoms ... CaudaEquina #Syndrome #MSK ... #pathophysiology ... #diagnosis #symptoms
Polyarteritis Nodosa (PAN): Pathogenesis and Clinical Findings

Medical Comorbidities Malignancies (most commonly hairy-cell leukemia)
Immunogenetic Predisposition: patient is
Viral replication causes ... direct injury to ... PolyarteritisNodosa #Pathophysiology ... Diagnosis #Signs #Symptoms
Chronic Hypertensive Retinopathy: Pathogenesis and clinical findings

Ophthalmic Artery Hypertension
Stage 1: Mild/vasoconstrictive
 • Acute and chronic vasospasm
hyalinization causes ... BRB breakdown causes ... #Retinopathy #pathophysiology ... #ophthalmology ... diagnosis #signs #symptoms