The Calgary Guide to Understanding Disease @TheCalgaryGuide
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Account created for The Calgary Guide to Understanding Disease - Linking pathophysiology to clinical presentation - http://calgaryguide.ucalgary.ca/
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pathophysiology symptoms diagnosis orthopedics achilles anorexianervosa causes endocrinology femoralhead gh growthhormone osteomalacia overproduction pagetsdisease psychiatry rickets stressfractures tendonrupture trendelenburg
Stress Fracture: Pathogenesis and clinical findings Abnormal biomechanics, Repetitive impact activities => Repetitive subthreshold mechanical loading => Bone strain =>
Stress Fracture: ... Accumulated micro-damage exceeds ... => Microscopic fractures ... StressFractures #msk ... pathophysiology #symptoms #signs
Femoral Head Fracture: Pathogenesis and clinical findings • Posterior hip dislocation -> Impaction force from femoral
Femoral Head Fracture ... onto lateral hip Signs ... /Symptoms/Complications ... #msk #diagnosis ... pathophysiology #signs
Growth Hormone Excess - Pathogenesis and clinical findings • Acromegaly and gigantism share the same pathophysiology
Growth Hormone Excess ... GH excess prior ... Acne • Coarse features ... tolerance • Weight gain ... Overproduction #diagnosis #signs
Trendelenburg Gait: Pathogenesis and clinical findings Skeletal Pathology of the Hip • Arthritis • Congenital hip dysplasia
Trendelenburg Gait ... Greater Trochanter Fracture ... Trendelenburg Gait ... causes #symptoms #signs ... #diagnosis #msk
Achilles Tendon Rupture - Pathogenesis and clinical findings • The Achilles tendon is 15cm long in
pre-determined etiology Signs ... /Symptoms/Complications ... rupture - Antalgic gait ... TendonRupture #diagnosis #signs ... pathophysiology #msk
Rickets and Osteomalacia: Pathogenesis and Clinical Findings • Calcification inhibitors (excess exposure to A1, Fluoride, etidronate)
Calcification inhibitors (excess ... Bowed legs • Fractures ... manifesting often as gait ... pathophysiology #diagnosis #signs
Anorexia Nervosa: Complications CARDIAC ABNORMALITIES - Functional: Low BP, Sinus bradycardia, prolonged QT interval - Structural: Reduced
Anorexia Nervosa: Complications ... increased risk of fracture ... - Lethargy or Excess ... Death - Cardiac complications ... pathophysiology #diagnosis #signs
Paget’s Disease: Complications Abnormal Osteoclasts cause excessive bone turnover -> Incr bone resorption, Incr (abnormal) bone formation MSK
Paget’s Disease: Complications ... bone formation MSK ... -> Pathologic fractures ... pathophysiology #diagnosis #signs ... #symptoms #complications
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