The Calgary Guide to Understanding Disease @TheCalgaryGuide
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pathophysiology signs symptoms complications sle stages adhesivecapsulitis caudaequina comparison degenerative differential diffuse disruptors erythematosus fracture frozenshoulder healing inflammatory jointdisease jointpain
Systemic Lupus Erythematosus (SLE): Musculoskeletal Manifestations • Immune Complex Deposition - Arthralgia, Arthritis
Systemic Lupus Erythematosus ... #Systemic #Lupus ... Erythematosus #SLE #MSK ... signs #symptoms #diagnosis
Lupus (SLE): Mucocutaneous Manifestations • Langerhan cells and keratinocytes release cytokines -> localized inflammatory response ->
Lupus (SLE): Mucocutaneous ... Subacute cutaneous lupus ... with keratotic scaling ... Phenomenon #Lupus ... pathophysiology #diagnosis
Meralgia paresthetica: Pathogenesis and Clinical Findings Compression/injury of Lateral Femoral Cutaneous Nerve (LFCN) -> Meralgia paresthetica •
sensory • Before diagnosis ... Tingling, Burning, Stinging ... , Stabbing) - ... MeralgiaParesthetica #MSK ... #differential #diagnosis
Radiculopathy: Signs and Symptoms • Back/Neck Pain • Decr Range of motion • Abnormal posturing •
: -> Shooting, stabbing ... Radiculopathy #MSK ... #diagnosis #signs
Cauda Equina Syndrome Causes: • Large lumbar degenerative disc herniation (central) • Severe lumbar spondylosis • Neoplasm
pain (shooting, stabbing ... CaudaEquina #Syndrome #MSK ... pathophysiology #diagnosis
Adhesive Capsulitis (Frozen Shoulder) - Pathogenesis and Clinical Findings • Primary (Idiopathic): Unknown etiology, but associated
pathophysiology #diagnosis ... signs #stages #staging ... #msk
Distinguishing between Inflammatory and Degenerative joint disease Inflammatory Joint Disease • Swelling stimulates joint nociceptors -> Pain
Rheumatoid arthritis, Lupus ... Comparison #Versus #MSK ... JointDisease #JointPain #Diagnosis
Diffuse Systemic Sclerosis (Scleroderma) - Pulmonary Fibrosis -> Crackles, Abnormal CXR - Pulmonary Hypertension, Right Heart
Renal Failure - Mask ... (i.e. a "purse-string ... signs #symptoms #diagnosis
Fracture Healing (and disruptors of this process) Inflammatory Stage (0-7d) • Fracture disrupts local blood vessels ->
#Orthopedics #msk ... #Staging #pathophysiology ... #diagnosis #disruptors
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