The Calgary Guide to Understanding Disease @TheCalgaryGuide
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Account created for The Calgary Guide to Understanding Disease - Linking pathophysiology to clinical presentation - http://calgaryguide.ucalgary.ca/
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diagnosis signs symptoms orthopedics gh growthhormone stages staging adhesivecapsulitis bulimianervosa complications degenerative differential disruptors feedbackloop femur fracture frozenshoulder gait healing
Stress Fracture: Pathogenesis and clinical findings Abnormal biomechanics, Repetitive impact activities => Repetitive subthreshold mechanical loading => Bone strain =>
Stress Fracture: ... Accumulated micro-damage exceeds ... => Microscopic fractures ... StressFractures #msk ... #orthopedics #pathophysiology
Subtrochanteric Femur Fracture: Pathogenesis and clinical findings • Subtrochanteric region spans 5 cm distally from the
in elderly Causes ... Major trauma -> An excess ... #msk #orthopedics ... #differential #causes ... #pathophysiology
Growth Hormone Excess - Pathogenesis and clinical findings • Acromegaly and gigantism share the same pathophysiology
share the same pathophysiology ... • Other rare causes ... Acne • Coarse features ... signs #symptoms #endocrinology ... #pathophysiology
Feedback Loop: Growth Hormone (GH) Growth Hormone: • Liver -> GHR activates JAK-STAT pathway -> Incr IGF1
deficiency: - Short ... lipid • GH excess ... #FeedbackLoop #endocrinology ... #pathophysiology
Trendelenburg Gait: Pathogenesis and clinical findings Skeletal Pathology of the Hip • Arthritis • Congenital hip dysplasia
Greater Trochanter Fracture ... Trendelenburg #Gait #pathophysiology ... #causes #symptoms ... signs #diagnosis #msk
Menstrual Cycle Physiology: Correlating the Ovarian and Uterine Cycles Note: Some charts show different relative levels of
days long) • Starts ... , progesterone causes ... #OvarianCycle #pathophysiology ... #comparison #endocrinology
Adhesive Capsulitis (Frozen Shoulder) - Pathogenesis and Clinical Findings • Primary (Idiopathic): Unknown etiology, but associated
, humeral head fracture ... a stroke that caused ... FrozenShoulder #pathophysiology ... stages #staging #msk
Distinguishing between Inflammatory and Degenerative joint disease Inflammatory Joint Disease • Swelling stimulates joint nociceptors -> Pain
> Stiffness is short-lived ... #Degenerative #Comparison ... #Versus #MSK #JointDisease ... JointPain #Diagnosis #pathophysiology
Rickets and Osteomalacia: Pathogenesis and Clinical Findings • Calcification inhibitors (excess exposure to A1, Fluoride, etidronate)
Calcification inhibitors (excess ... closure => • Short ... Bowed legs • Fractures ... #Osteomalacia #pathophysiology
Paget’s Disease: Complications Abnormal Osteoclasts cause excessive bone turnover -> Incr bone resorption, Incr (abnormal) bone formation MSK
Abnormal Osteoclasts cause ... bone formation MSK ... -> Pathologic fractures ... Skull expansion causes ... PagetsDisease #pathophysiology
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