The Calgary Guide to Understanding Disease @TheCalgaryGuide
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Account created for The Calgary Guide to Understanding Disease - Linking pathophysiology to clinical presentation - http://calgaryguide.ucalgary.ca/
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pathophysiology diagnosis signs gh growthhormone orthopedics adhesivecapsulitis bulimianervosa complications differential feedbackloop femur frozenshoulder gait menstrualcycle osteomalacia ovariancycle overproduction pagetsdisease pituitary
Stress Fracture: Pathogenesis and clinical findings Abnormal biomechanics, Repetitive impact activities => Repetitive subthreshold mechanical loading => Bone strain =>
Stress Fracture: ... Accumulated micro-damage exceeds ... => Microscopic fractures ... StressFractures #msk ... pathophysiology #symptoms
Subtrochanteric Femur Fracture: Pathogenesis and clinical findings • Subtrochanteric region spans 5 cm distally from the
Subtrochanteric Femur Fracture ... in elderly Causes ... Major trauma -> An excess ... #msk #orthopedics ... #differential #causes
Growth Hormone Excess - Pathogenesis and clinical findings • Acromegaly and gigantism share the same pathophysiology
Growth Hormone Excess ... • Other rare causes ... Acne • Coarse features ... diagnosis #signs #symptoms ... #endocrinology
Feedback Loop: Growth Hormone (GH) Growth Hormone: • Liver -> GHR activates JAK-STAT pathway -> Incr IGF1
lipolysis Signs/Symptoms ... deficiency: - Short ... lipid • GH excess ... #FeedbackLoop #endocrinology
Trendelenburg Gait: Pathogenesis and clinical findings Skeletal Pathology of the Hip • Arthritis • Congenital hip dysplasia
Greater Trochanter Fracture ... pathophysiology #causes ... #symptoms #signs ... #diagnosis #msk
Adhesive Capsulitis (Frozen Shoulder) - Pathogenesis and Clinical Findings • Primary (Idiopathic): Unknown etiology, but associated
, humeral head fracture ... a stroke that caused ... pathophysiology #diagnosis #symptoms ... stages #staging #msk
Menstrual Cycle Physiology: Correlating the Ovarian and Uterine Cycles Note: Some charts show different relative levels of
days long) • Starts ... , progesterone causes ... pathophysiology #comparison ... #endocrinology
Rickets and Osteomalacia: Pathogenesis and Clinical Findings • Calcification inhibitors (excess exposure to A1, Fluoride, etidronate)
Calcification inhibitors (excess ... closure => • Short ... Bowed legs • Fractures ... diagnosis #signs #symptoms
Paget’s Disease: Complications Abnormal Osteoclasts cause excessive bone turnover -> Incr bone resorption, Incr (abnormal) bone formation MSK
Abnormal Osteoclasts cause ... bone formation MSK ... -> Pathologic fractures ... Skull expansion causes ... diagnosis #signs #symptoms
Bulimia Nervosa: Signs and Symptoms Associated Psychological / Behavioural Features • Feelings of shame, guilt and embarrassment
Nervosa: Signs and Symptoms ... / Behavioural Features ... vomiting Other • Symptoms ... Russell's Sign • Sores ... , scars, calluses
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