The Calgary Guide to Understanding Disease @TheCalgaryGuide
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Account created for The Calgary Guide to Understanding Disease - Linking pathophysiology to clinical presentation - http://calgaryguide.ucalgary.ca/
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Stress Fracture: Pathogenesis and clinical findings
Abnormal biomechanics, Repetitive impact activities
=> Repetitive subthreshold mechanical loading
=> Bone strain
=>
Stress Fracture: ... => Microscopic fractures ... StressFractures #msk ... pathophysiology #symptoms ... #signs
Femoral Head Fracture: Pathogenesis and clinical findings
 • Posterior hip dislocation -> Impaction force from femoral
onto lateral hip Signs ... /Symptoms/Complications ... #msk #diagnosis ... pathophysiology #signs ... #symptoms #orthopedics
Radiculopathy: Signs and Symptoms
 • Back/Neck Pain
 • Decr Range of motion
 • Abnormal posturing
 •
Radiculopathy: Signs ... and Symptoms ... : -> Shooting, stabbing ... Radiculopathy #MSK ... #symptoms #pathophysiology
Meralgia paresthetica: Pathogenesis and Clinical Findings
Compression/injury of Lateral Femoral Cutaneous Nerve (LFCN) -> Meralgia paresthetica
 •
Tingling, Burning, Stinging ... , Stabbing) - ... MeralgiaParesthetica #MSK ... differential #diagnosis #signs ... #symptoms
Spondylolysis & Spondylolisthesis: Pathogenesis and Clinical Findings

Pars interarticularis stress fracture (spondylolysis) - most frequently in the
interarticularis stress fracture ... XR — scotty dog sign ... Spondylolisthesis #MSK ... pathophysiology #signs ... #symptoms
Rheumatoid arthritis (RA): Extra-articular manifestations
Skin: 
 • Inflammation of skin (esp. over areas of stress) forms
Rheumatoid arthritis (RA ... blood vessels (vasculitis ... effusion on CXR • RA ... pathophysiology #signs ... #symptoms #diagnosis
Cauda Equina Syndrome
Causes:
 • Large lumbar degenerative disc herniation (central)
 • Severe lumbar spondylosis
 • Neoplasm
lumbar spine Signs ... / Symptoms / Complications ... pain (shooting, stabbing ... CaudaEquina #Syndrome #MSK ... #signs
Rheumatoid arthritis (RA): Pathogenesis and Joint diseases features
 • RA affects 1% of population, women >
Joint diseases features ... • RA affects ... Extra-articular signs ... pathophysiology #signs ... #symptoms #diagnosis
Lupus (SLE): Mucocutaneous Manifestations

 • Langerhan cells and keratinocytes release cytokines -> localized inflammatory response ->
exposed areas -> Scaring ... with keratotic scaling ... Livedo Reticularis, Vasculitis ... pathophysiology #diagnosis #signs ... #symptoms #complications
Trendelenburg Gait: Pathogenesis and clinical findings

Skeletal Pathology of the Hip
 • Arthritis
 • Congenital hip dysplasia
Greater Trochanter Fracture ... pathophysiology #causes #symptoms ... #signs #diagnosis ... #msk