The Calgary Guide to Understanding Disease @TheCalgaryGuide
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Gout: Pathogenesis and Clinical Findings
 - Conditions of rapid cell turnover: hemolysis, psoriasis, lymphoproliferative disorders
 -
Gout: Pathogenesis ... Medications (ASA, ACE ... Chronic tophaceous gout ... Complications #Gout
Humoral Immunity - Pathogenesis and Clinical Findings
Antigens (Ag) are produced from pathogens (bacteria, viruses, fungi, parasites)
cell-independent Ag: Ags ... such as peptides ... Ags tagged with ... Opsonization: Abs ... Neutralization: Abs
Acute Compartment Syndrome
 • Crush injuries, burns, circumferential constriction to limbs (each containing facially divided muscle
CompartmentSyndrome #ACS ... pathophysiology #orthopedics
Open Fractures: Mechanisms, Clinical Features and Complications
Gustilo-Anderson Classification:
 • Type I
   - Wound <
Typically "inside out ... Complications #MSK #Orthopedics
First Generation Anti-Psychotics: Mechanisms and Side Effects
Typical/Conventional Anti-Psychotics - Examples: Haloperidol, Chlorpromazine

ACh M1 antagonist - Block
Chlorpromazine ACh ... Block action of ACh ... throughout body (mouth, gut
Hyperuricemia: Pathogenesis and Complications

 - Hypercalcemia (due to diseases like Sarcoidosis and Hyperparathyroidism) -> Accumulation of
renal tubules - ACE-inhibitors ... Complications #Gout
Necrotizing Fasciitis: Pathogenesis and Clinical Findings

#NecrotizingFasciitis #pathophysiology #orthopedics
pathophysiology #orthopedics
Stress Fracture: Pathogenesis and clinical findings
Abnormal biomechanics, Repetitive impact activities
=> Repetitive subthreshold mechanical loading
=> Bone strain
=>
StressFractures #msk #orthopedics
The Neuroanatomy and Physiology of Emotion
 • Thalamus
 • Primary and Association Cortices
 • The Prefrontal
Nervous System (ANS ... ) -> The ANS automatically
Second Generation Antipsychotics: Mechanisms and Side Effects
(Atypical Anti-Psychotics) - Examples: Clozapine, Olanzapine, Quetiapine, Risperidone, Zotepine, Paliperidone,
As such, it is considered ... Antagonism - Block ACh ... Gut, mouth, eyes