The Calgary Guide to Understanding Disease @TheCalgaryGuide
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diagnosis signs symptoms retinopathy achilles ankylosingspondylitis cataracts cholesteatoma chronic closedangle diabetes extraarticular hypertensive manifestations middleear msk openangle retinoblastoma tendonrupture
Retinoblastoma: Pathogenesis and clinical findings • Sporadic mutation -> One allele of RB1 tumor suppressor gene
Signs / Symptoms / Complications ... Pseudo-hypopyon • Secondary ... glaucoma • Strabismus ... Retinoblastoma #pathophysiology ... #ophthalmology
Acute Closed Angle Glaucoma: Pathogenesis and Clinical Findings OPHTHALMIC EMERGENCY: Early detection is essential, but most patients
Acute Closed Angle ... Signs / Symptoms / Complications ... Photophobia #Acute ... #pathophysiology ... #ophthalmology
Diabetic Retinopathy: Pathogenesis and clinical findings Mild Non-proliferative DR • Outpouchings of the weakened capillary walls or
Diabetic Retinopathy ... #Retinopathy #Diabetes ... #ophthalmology ... #diagnosis #complications ... #pathophysiology
Achilles Tendon Rupture - Pathogenesis and clinical findings • The Achilles tendon is 15cm long in
warriors") • Acute ... Signs/Symptoms/Complications ... signs #symptoms #pathophysiology ... #msk #orthopedics
Chronic Hypertensive Retinopathy: Pathogenesis and clinical findings Ophthalmic Artery Hypertension Stage 1: Mild/vasoconstrictive • Acute and chronic vasospasm
vasoconstrictive • Acute ... #Retinopathy #pathophysiology ... #ophthalmology ... signs #symptoms #complications
Secondary Glaucoma: Pathogenesis and Clinical Findings Open-Angle Secondary Glaucoma: • Pre-trabecular defect -> Aqueous outflow is obstructed
Secondary Glaucoma ... Findings Open-Angle Secondary ... Glaucoma: • Pre-trabecular ... #Glaucoma #pathophysiology ... #ophthalmology
Cataract: Pathogenesis and clinical findings Increased Age (most common) -> Ultraviolet light, radiation, toxins ->Denaturation and abnormal
meshwork contact -> Secondary ... angle closure glaucoma ... #cataracts #pathophysiology ... #ophthalmology
Primary Open-Angle Glaucoma: Pathogenesis and Clinical Findings • Risk factors -> Incr IOP, Incr age, African-American
Primary Open-Angle Glaucoma ... family history, diabetes ... central vision #Secondary ... #pathophysiology ... #ophthalmology
Cholesteatoma (of middle ear): Pathogenesis and clinical findings • Congenital trapping of keratinizing epithelium in middle
Signs / Symptoms / Complications ... • Aural Polyp secondary ... inflammation • Acute ... Cholesteatoma #MiddleEar #pathophysiology ... signs #diagnosis #complications
Ankylosing Spondylitis: Extra-articular Manifestations • Ocular - Inflammation of the iris, the anterior part of the
- Inflammation acute ... in glomeruli -> Secondary ... Manifestations #Complications ... #pathophysiology
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