The Calgary Guide to Understanding Disease @TheCalgaryGuide
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Account created for The Calgary Guide to Understanding Disease - Linking pathophysiology to clinical presentation - http://calgaryguide.ucalgary.ca/
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Stress Fracture: Pathogenesis and clinical findings
Abnormal biomechanics, Repetitive impact activities
=> Repetitive subthreshold mechanical loading
=> Bone strain
=>
Stress Fracture: ... => Microscopic fractures ... loading Stress Fracture ... StressFractures #msk #orthopedics ... pathophysiology #symptoms
Subtrochanteric Femur Fracture: Pathogenesis and clinical findings
 • Subtrochanteric region spans 5 cm distally from the
Subtrochanteric Femur Fracture ... low energy fall fractures ... in elderly Causes ... #msk #orthopedics ... #differential #causes
Femoral Head Fracture: Pathogenesis and clinical findings
 • Posterior hip dislocation -> Impaction force from femoral
Femoral Head Fracture ... lateral hip Signs/Symptoms ... • Non-union of fracture ... pathophysiology #signs #symptoms ... #orthopedics
Fracture Healing (and disruptors of this process)
Inflammatory Stage (0-7d)
 • Fracture disrupts local blood vessels ->
(and disruptors ... disrupts local ... Fluoroquinolones - Causes ... #Stages #Orthopedics ... pathophysiology #diagnosis #disruptors
Growth Hormone Excess - Pathogenesis and clinical findings
 • Acromegaly and gigantism share the same pathophysiology
• Other rare causes ... Acne • Coarse features ... diagnosis #signs #symptoms
Trendelenburg Gait: Pathogenesis and clinical findings

Skeletal Pathology of the Hip
 • Arthritis
 • Congenital hip dysplasia
Greater Trochanter Fracture ... pathophysiology #causes ... #symptoms #signs
Adhesive Capsulitis (Frozen Shoulder) - Pathogenesis and Clinical Findings

 • Primary (Idiopathic): Unknown etiology, but associated
, humeral head fracture ... a stroke that caused ... pathophysiology #diagnosis #symptoms
Bulimia Nervosa: Signs and Symptoms
Associated Psychological / Behavioural Features
 • Feelings of shame, guilt and embarrassment
Nervosa: Signs and Symptoms ... / Behavioural Features ... vomiting Other • Symptoms ... Sores, scars, calluses ... diagnosis #signs #symptoms
Paget’s Disease: Complications
Abnormal Osteoclasts cause excessive bone turnover -> Incr bone resorption, Incr (abnormal) bone formation

MSK
Abnormal Osteoclasts cause ... -> Pathologic fractures ... Skull expansion causes ... middle ear bones causes ... diagnosis #signs #symptoms
Serotonin Syndrome: Pathogenesis and Clinical Findings
Serotonin Syndrome: Variable combination of mental status changes, autonomic instability, and
ingestion and most cases ... following clinical features ... Diagnosis #Signs #Symptoms