The Calgary Guide to Understanding Disease @TheCalgaryGuide
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Account created for The Calgary Guide to Understanding Disease - Linking pathophysiology to clinical presentation - http://calgaryguide.ucalgary.ca/
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pathophysiology signs complications msk sle alcohol alcoholusedisorder avascularnecrosis erythematosus fracture healing manifestations mucocutaneous musculoskeletal psychiatry stages staging systemic withdrawal
Alcohol Use Disorder: Pathogenesis and Clinical Findings • Tolerance (reduced sensitivity to effects of EtOH) •
to effects of EtOH ... • Withdrawal symptoms ... , tachycardia, nausea ... Pathophysiology #Diagnosis ... #Signs #Symptoms
Systemic Lupus Erythematosus (SLE): Musculoskeletal Manifestations • Immune Complex Deposition - Arthralgia, Arthritis
Systemic Lupus Erythematosus ... Myopathy (Also caused ... #Systemic #Lupus ... pathophysiology #signs #symptoms ... #diagnosis
Lupus (SLE): Mucocutaneous Manifestations • Langerhan cells and keratinocytes release cytokines -> localized inflammatory response ->
Lupus (SLE): Mucocutaneous ... Subacute cutaneous lupus ... hair follicles -> causes ... pathophysiology #diagnosis ... #signs #symptoms
Fracture Healing (and disruptors of this process) Inflammatory Stage (0-7d) • Fracture disrupts local blood vessels ->
) • Fracture disrupts ... Fluoroquinolones - Causes ... Healing #Stages #Orthopedics ... pathophysiology #diagnosis ... #disruptors
Alcohol Withdrawal: Clinical Findings and Complications The onset of alcohol withdrawal generally begins 6-24 hours after the
Symptoms typically ... >2 days after EtOH ... dreams, anorexia, nausea ... Pathophysiology #Diagnosis ... #EtOH
Avascular Necrosis: Pathogenesis and Clinical Findings • Physical Trauma (esp. to the scaphoid bone with damage
) • Multiple causes ... therapy - Lupus ... pathophysiology #diagnosis ... #signs #symptoms
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