The Calgary Guide to Understanding Disease @TheCalgaryGuide
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diagnosis pathophysiology signs complications sle erythematosus msk systemic avascularnecrosis extraarticular fracture gastrointestinal healing mucocutaneous musculoskeletal pan polyarteritisnodosa ra rheumatoidarthritis stages
Systemic Lupus Erythematosus (SLE): Musculoskeletal Manifestations • Immune Complex Deposition - Arthralgia, Arthritis
Systemic Lupus Erythematosus ... Musculoskeletal Manifestations ... Myopathy (Also caused ... #Systemic #Lupus ... pathophysiology #signs #symptoms
Systemic Lupus Erythematosus: Gastrointestinal Manifestations - Thrombosis of vessels in the pancreas, Vasculitis -> Acute Pancreatitis
Systemic Lupus Erythematosus ... Gastrointestinal Manifestations ... #Systemic #Lupus ... pathophysiology #signs #symptoms
Lupus (SLE): Mucocutaneous Manifestations • Langerhan cells and keratinocytes release cytokines -> localized inflammatory response ->
Lupus (SLE): Mucocutaneous ... Manifestations ... hair follicles -> causes ... Mucocutaneous #Manifestations ... diagnosis #signs #symptoms
Polyarteritis Nodosa (PAN): Pathogenesis and Clinical Findings Medical Comorbidities Malignancies (most commonly hairy-cell leukemia) Immunogenetic Predisposition: patient is
Viral replication causes ... swelling - GI Manifestations ... Diagnosis #Signs #Symptoms
Rheumatoid arthritis (RA): Extra-articular manifestations Skin: • Inflammation of skin (esp. over areas of stress) forms
Extra-articular manifestations ... inflammation tends to cause ... pathophysiology #signs #symptoms
Fracture Healing (and disruptors of this process) Inflammatory Stage (0-7d) • Fracture disrupts local blood vessels ->
Fracture Healing (and disruptors ... ) • Fracture disrupts ... Fluoroquinolones - Causes ... Healing #Stages #Orthopedics ... pathophysiology #diagnosis #disruptors
Avascular Necrosis: Pathogenesis and Clinical Findings • Physical Trauma (esp. to the scaphoid bone with damage
) • Multiple causes ... therapy - Lupus ... diagnosis #signs #symptoms
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