The Calgary Guide to Understanding Disease @TheCalgaryGuide
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diagnosis pathophysiology signs psychiatry complications sle behavioraldisorder erythematosus msk allergy anorexianervosa antipsychotics anxiety avascularnecrosis firstgeneration fracture gastrointestinal healing hypersensitivityreaction immunology
Systemic Lupus Erythematosus (SLE): Musculoskeletal Manifestations • Immune Complex Deposition - Arthralgia, Arthritis
Systemic Lupus Erythematosus ... Myopathy (Also caused ... Osteoporosis #Systemic ... #Lupus #Erythematosus ... pathophysiology #signs #symptoms
Systemic Lupus Erythematosus: Gastrointestinal Manifestations - Thrombosis of vessels in the pancreas, Vasculitis -> Acute Pancreatitis
Systemic Lupus Erythematosus ... distension #Systemic ... #Lupus #Erythematosus ... pathophysiology #signs #symptoms
Type III Hypersensitivity: Pathogenesis and clinical findings Definition: Small antigen-antibody complexes (produced from normal immune response to
self-antigens are the cause ... : • Systemic Lupus ... antigens are the cause
Primary Sjogren’s Syndrome: Pathogenesis and Clinical Findings • Primary Sjögren's is a solitary process whereas secondary Sjögren's
(PBC), or with systemic ... arthritis (RA) or systemic ... lupus erythematosus ... (SLE) Signs / Symptoms ... Diagnosis #Signs #Symptoms
Lupus (SLE): Mucocutaneous Manifestations • Langerhan cells and keratinocytes release cytokines -> localized inflammatory response ->
Lupus (SLE): Mucocutaneous ... Subacute cutaneous lupus ... hair follicles -> causes ... Phenomenon #Lupus ... diagnosis #signs #symptoms
Schizophrenia: Pathogenesis and Symptoms Increased dopaminergic transmission in mesolimbic projection -> Dopaminergic neurons here project into the limbic
Pathogenesis and Symptoms ... into the limbic system ... is thought to cause ... the Positive Symptoms ... is thought to cause
First Generation Anti-Psychotics: Mechanisms and Side Effects Typical/Conventional Anti-Psychotics - Examples: Haloperidol, Chlorpromazine ACh M1 antagonist - Block
VTA -> limbic system ... Extrapyramidal Symptoms ... , and/or limbs caused
Fracture Healing (and disruptors of this process) Inflammatory Stage (0-7d) • Fracture disrupts local blood vessels ->
Fracture Healing (and disruptors ... ) • Fracture disrupts ... Fluoroquinolones - Causes ... Healing #Stages #Orthopedics ... pathophysiology #diagnosis #disruptors
Panic Disorder: Pathogenesis and clinical findings Social Factors • Parenting and infant attachment • Childhood illness/abuse •
autononomic nervous system ... trigger Physical Symptoms ... sweating, trembling, nausea ... Psychological Symptoms ... Uncontrollable fear about symptoms
Avascular Necrosis: Pathogenesis and Clinical Findings • Physical Trauma (esp. to the scaphoid bone with damage
) • Multiple causes ... therapy - Lupus ... diagnosis #signs #symptoms
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