The Calgary Guide to Understanding Disease @TheCalgaryGuide
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Retinoblastoma: Pathogenesis and clinical findings
 • Sporadic mutation -> One allele of RB1 tumor suppressor gene
Pseudo-hypopyon • Secondary ... Retinoblastoma #pathophysiology ... #ophthalmology
Periorbital Cellulitis: Pathogenesis and Clinical Findings
Definitions:
a. Dacryoadenitis: infection of the lacrimal glands
b. Conjunctivitis: inflammation of the
lacrimal sac, secondary ... Periorbital #Cellulitis #pathophysiology ... #ophthalmology
Acute Closed Angle Glaucoma: Pathogenesis and Clinical Findings
OPHTHALMIC EMERGENCY: Early detection is essential, but most patients
Acute Closed Angle ... Photophobia #Acute ... ClosedAngle #Glaucoma #pathophysiology ... #ophthalmology
Central Retinal Artery Occlusion: Pathogenesis and clinical findings
 • Inflammatory Disease: (i.e. GCA, SLE, GPA) ->
trucking" • Acute ... Occlusion #CRAO #pathophysiology ... #ophthalmology
Chronic Hypertensive Retinopathy: Pathogenesis and clinical findings

Ophthalmic Artery Hypertension
Stage 1: Mild/vasoconstrictive
 • Acute and chronic vasospasm
vasoconstrictive • Acute ... #Retinopathy #pathophysiology ... #ophthalmology
Cataract: Pathogenesis and clinical findings

Increased Age (most common) -> Ultraviolet light, radiation, toxins ->Denaturation and abnormal
meshwork contact -> Secondary ... #cataracts #pathophysiology ... #ophthalmology
Secondary Glaucoma: Pathogenesis and Clinical Findings
Open-Angle Secondary Glaucoma:
 • Pre-trabecular defect -> Aqueous outflow is obstructed
Secondary Glaucoma ... Findings Open-Angle Secondary ... Closed-Angle Secondary ... #Glaucoma #pathophysiology ... #ophthalmology
Cholesteatoma (of middle ear): Pathogenesis and clinical findings
 • Congenital trapping of keratinizing epithelium in middle
• Aural Polyp secondary ... inflammation • Acute ... Cholesteatoma #MiddleEar #pathophysiology
Ankylosing Spondylitis: Extra-articular Manifestations
 • Ocular - Inflammation of the iris, the anterior part of the
- Inflammation acute ... in glomeruli -> Secondary ... Complications #pathophysiology
Primary Open-Angle Glaucoma: Pathogenesis and Clinical Findings
 • Risk factors -> Incr IOP, Incr age, African-American
central vision #Secondary ... OpenAngle #Glaucoma #pathophysiology ... #ophthalmology