The Calgary Guide to Understanding Disease @TheCalgaryGuide
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Account created for The Calgary Guide to Understanding Disease - Linking pathophysiology to clinical presentation - http://calgaryguide.ucalgary.ca/
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Stress Fracture: Pathogenesis and clinical findings
Abnormal biomechanics, Repetitive impact activities
=> Repetitive subthreshold mechanical loading
=> Bone strain
=>
Stress Fracture: ... subthreshold mechanical loading ... from continued loading ... StressFractures #msk #orthopedics ... #pathophysiology
Classification of Pelvic Ring Fractures: Mechanisms, Clinical Features and Complications
 • Anterior Posterior Compression (APC) -
and Complications ... Classification #Grades #Grading ... #Orthopedics #MSK ... #diagnosis #complications ... #pathophysiology
Diabetic Retinopathy: Pathogenesis and clinical findings

Mild Non-proliferative DR
 • Outpouchings of the weakened capillary walls or
Diabetic Retinopathy ... ischemia -> Venous beading ... #Retinopathy #Diabetes ... ophthalmology #diagnosis #complications ... #pathophysiology
Retinopathy of Prematurity: Pathogenesis and clinical findings
Increased metabolic demand of growing eye
-> Excessive VEGF production ->
Retinopathy of Prematurity ... -> Neovascular complications ... detachment #Retinopathy ... #Prematurity #peds ... #pediatrics #pathophysiology
Femoral Head Fracture: Pathogenesis and clinical findings
 • Posterior hip dislocation -> Impaction force from femoral
Femoral Head Fracture ... Signs/Symptoms/Complications ... • Non-union of fracture ... msk #diagnosis #pathophysiology ... signs #symptoms #orthopedics
Prader-Willi Syndrome: Pathogenesis and clinical findings
 • Maternal uniparental disomy: inheriting 2 copies of maternal chromosome
Signs/Symptoms/Complications ... Incr Skeletal fractures ... Obesity -> Type 2 diabetes ... Syndrome #genetics #pathophysiology ... #peds #pediatrics
Diabetic Foot: Pathogenesis and clinical findings
 • Polyol Pathway - Excess glucose enters Polyol pathway ->
Diabetic Foot: Pathogenesis ... in inopportune loading ... #DiabeticFoot #pathophysiology ... #complications ... #Diabetes
Bulimia Nervosa: Signs and Symptoms
Associated Psychological / Behavioural Features
 • Feelings of shame, guilt and embarrassment
/ Behavioural Features ... Problems and Facial Features ... Symptoms related to complications ... frequent urination (diabetes ... BulimiaNervosa #pathophysiology