The Calgary Guide to Understanding Disease @TheCalgaryGuide
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diagnosis signs symptoms lupus sle 21hydroxylasedeficiency 21ohd caudaequina cecs chronicexertional endocrinology erythematosus genetics manifestations mucocutaneous musculoskeletal pagetsdisease pediatrics syndrome systemic
Systemic Lupus Erythematosus (SLE): Musculoskeletal Manifestations • Immune Complex Deposition - Arthralgia, Arthritis
Myopathy (Also caused ... Erythematosus #SLE #MSK ... Musculoskeletal #Complications ... #pathophysiology
Cauda Equina Syndrome Causes: • Large lumbar degenerative disc herniation (central) • Severe lumbar spondylosis • Neoplasm
Equina Syndrome Causes ... Signs / Symptoms / Complications ... CaudaEquina #Syndrome #MSK ... #pathophysiology
Lupus (SLE): Mucocutaneous Manifestations • Langerhan cells and keratinocytes release cytokines -> localized inflammatory response ->
hair follicles -> causes ... Livedo Reticularis, Vasculitis ... Manifestations #pathophysiology ... signs #symptoms #complications
Chronic Exertional Compartment Syndrome (CECS) • Diagnosis Of CECS requires patient to undergo the same exertional
activity that causes ... ChronicExertional #CompartmentSyndrome ... #CECS #pathophysiology ... signs #symptoms #msk
21-Hydroxylase Deficiency (21-OHD): Pathogenesis and Clinical Findings Autosomal recessive mutation in CYP21A2 coding for the enzyme 21-OHase
enzyme 21-OHase causes ... Signs/Symptoms/Complications ... #21HydroxylaseDeficiency #21OHD #pathophysiology ... endocrinology #peds
Paget’s Disease: Complications Abnormal Osteoclasts cause excessive bone turnover -> Incr bone resorption, Incr (abnormal) bone formation MSK
Paget’s Disease: Complications ... Abnormal Osteoclasts cause ... bone formation MSK ... PagetsDisease #pathophysiology ... signs #symptoms #complications
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