The Calgary Guide to Understanding Disease @TheCalgaryGuide
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Selective Serotonin Reuptake Inhibitors: Mechanisms and Side Effects
 • Serotonin Syndrome:
   - Autonomic Hyperactivity:
Serotonin Reuptake Inhibitors ... • Serotonin Syndrome ... Dizziness - Nausea ... #Pathophysiology ... SideEffects #Psychiatry #Diagnosis
Serotonin-Norepinephrine Reuptake Inhibitors(SNRIs): Mechanisms and Side Effects

Withdrawal: Dizziness, Diarrhea, Insomnia, Nausea, Vomiting
Serotonin Syndrome - Potentially Life
Serotonin-Norepinephrine Reuptake Inhibitors ... Vomiting Serotonin Syndrome ... SerotoninNorepinephrine #Inhibitors ... #Pathophysiology ... SideEffects #Psychiatry #Diagnosis
Alcohol Use Disorder: Pathogenesis and Clinical Findings

 • Tolerance (reduced sensitivity to effects of EtOH)
 •
to effects of EtOH ... exacerbated by EtOH ... , tachycardia, nausea ... #Pathophysiology ... #Diagnosis #Signs
Growth Hormone Excess - Pathogenesis and clinical findings
 • Acromegaly and gigantism share the same pathophysiology
share the same pathophysiology ... • Other rare causes ... Carpal Tunnel Syndrome ... Overproduction #diagnosis ... endocrinology #pathophysiology
Alzheimer’s Disease: Pathogenesis and Clinical Findings
Risk factor for Late Onset Alzheimer's (99% of cases):
 - Increasing
Alzheimer's (99% of cases ... Alzheimer's (1% of cases ... mutations - Down syndrome ... AlzheimersDisease #Dementia #pathophysiology ... #geriatrics #diagnosis
Cauda Equina Syndrome
Causes:
 • Large lumbar degenerative disc herniation (central)
 • Severe lumbar spondylosis
 • Neoplasm
Cauda Equina Syndrome ... Causes: • Large ... #CaudaEquina #Syndrome ... #MSK #pathophysiology ... #diagnosis #symptoms
IgA Vasculitis – Henoch Scholein Purpura: Pathogenesis and Clinical Findings

 - Infectious Agents - 50% have
necrosis factor a inhibitors ... periumbilical region), nausea ... nephrotic/nephritic syndrome ... HenochScholeinPurpura #Pathophysiology ... #Diagnosis #Signs
Acquired Disorders of Reduced Bone Strength: Pathogenesis
 • Hyperparathyroidism
 • Vitamin D deficiency
 • Malabsorption syndromes
Malabsorption syndromes ... Diabetes • Other causes ... • Aromatase inhibitors ... #BoneStrength #pathophysiology ... #differential #diagnosis
Medical Conditions Causing Mania or Mania-Like Episodes: Pathogenesis
 • Bipolar Disorder -> Combination of individual, genetic,
circuitry -> Decreased Inhibitory ... Manic #Secondary #Causes ... #Differential #Diagnosis ... #Pathophysiology
Bulimia Nervosa: Signs and Symptoms
Associated Psychological / Behavioural Features
 • Feelings of shame, guilt and embarrassment
Sores, scars, calluses ... inducing vomiting #BulimiaNervosa ... #pathophysiology ... #diagnosis #signs