The Calgary Guide to Understanding Disease @TheCalgaryGuide
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Account created for The Calgary Guide to Understanding Disease - Linking pathophysiology to clinical presentation - http://calgaryguide.ucalgary.ca/
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Systemic Lupus Erythematosus (SLE): Musculoskeletal Manifestations

 • Immune Complex Deposition
    - Arthralgia, Arthritis
- Arthralgia, Arthritis ... Myopathy (Also caused ... Erythematosus #SLE #MSK ... pathophysiology #signs
Trendelenburg Gait: Pathogenesis and clinical findings

Skeletal Pathology of the Hip
 • Arthritis
 • Congenital hip dysplasia
of the Hip • Arthritis ... pathophysiology #causes ... #symptoms #signs ... #diagnosis #msk
Rheumatoid arthritis (RA): Extra-articular manifestations
Skin: 
 • Inflammation of skin (esp. over areas of stress) forms
Rheumatoid arthritis ... inflammation tends to cause ... interstitial lung disease ... pathophysiology #signs
Central Retinal Artery Occlusion: Pathogenesis and clinical findings
 • Inflammatory Disease: (i.e. GCA, SLE, GPA) ->
• Inflammatory Disease ... • Hematologic Disease ... retinal edema caused ... pathophysiology #ophthalmology ... #diagnosis #signs
Acute Closed Angle Glaucoma: Pathogenesis and Clinical Findings
OPHTHALMIC EMERGENCY: Early detection is essential, but most patients
• The disease ... • Significant cause ... most frequent cause ... damage & blindness Signs ... pathophysiology #ophthalmology
Adhesive Capsulitis (Frozen Shoulder) - Pathogenesis and Clinical Findings

 • Primary (Idiopathic): Unknown etiology, but associated
mellitus, thyroid disease ... a stroke that caused ... diagnosis #symptoms #signs ... stages #staging #msk
Popliteal (Baker’s) Cyst: Pathogenesis and clinical findings
 • Idiopathic
 • Meniscal Lesions
 • Osteoarthritis
 • Rheumatoid
• Rheumatoid Arthritis ... underlying joint disease ... underlying joint disease ... Popliteal #BakersCyst #MSK ... pathophysiology #signs
Paget’s Disease: Complications
Abnormal Osteoclasts cause excessive bone turnover -> Incr bone resorption, Incr (abnormal) bone formation

MSK
Paget’s Disease: ... Abnormal Osteoclasts cause ... bone formation MSK ... Skull expansion causes ... pathophysiology #diagnosis #signs