The Calgary Guide to Understanding Disease @TheCalgaryGuide
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diagnosis pathophysiology symptoms immunology erythematosus hypersensitivityreaction lupus sle allergic anaphylaxis classification definitions gastrointestinal hypersensitivity msk musculoskeletal ra reactions rheumatoidarthritis takayasus
Type I Hypersensitivity: Pathogenesis and clinical findings Definition: Production of lgE Antibodies that bind to harmless allergens
Type I Hypersensitivity ... Patient's immune system ... cells recruited Complications ... : • Acute Asthma ... Anaphylaxis #TypeI
Hypersensitivity: Summary Type I Hypersensitivity: • Immunological Mediator: lgE • Immunological Target: Allergen Molecules • Ex: Antibiotic
Hypersensitivity: Summary Type ... conjunctivitis Type ... Graves' Disease Type ... complexes • Ex: Systemic ... Erythematosus, Reactive Arthritis
Type III Hypersensitivity: Pathogenesis and clinical findings Definition: Small antigen-antibody complexes (produced from normal immune response to
Type III Hypersensitivity ... the cause: • Systemic ... the cause: • Arthritis ... sickness #TypeIII #Type3 ... HypersensitivityReaction #Allergy
Systemic Lupus Erythematosus: Gastrointestinal Manifestations - Thrombosis of vessels in the pancreas, Vasculitis -> Acute Pancreatitis
Systemic Lupus Erythematosus ... Vasculitis -> Acute ... distension #Systemic ... Gastrointestinal #Complications ... pathophysiology #signs
Systemic Lupus Erythematosus (SLE): Musculoskeletal Manifestations • Immune Complex Deposition - Arthralgia, Arthritis
Systemic Lupus Erythematosus ... - Arthralgia, Arthritis ... Osteoporosis #Systemic ... Musculoskeletal #Complications ... pathophysiology #signs
Anaphylaxis: Signs and Symptoms Anaphylaxis: when any egg of three conditions is met: 1. Acute onset of skin/mucosal
Acute onset of skin ... exposure to a likely allergen ... exposure to known allergen ... symptoms in the acute ... / Symptoms / Complications
Rheumatoid arthritis (RA): Pathogenesis and Joint diseases features • RA affects 1% of population, women >
Rheumatoid arthritis ... • Non-specific Acute-phase ... deviation, etc • Systemic ... Extra-articular signs ... pathophysiology #signs
Takayasu’s Arteritis: Pathogenesis and clinical findings - Fatigue, weight loss, low grade fever, arthralgias - Incr
Takayasu’s Arteritis ... , Incr risk of Acute ... Syndrome - >10mmHg systolic ... #Takayasus #Arteritis ... Vasculitis #Diagnosis #Signs
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