The Calgary Guide to Understanding Disease @TheCalgaryGuide
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Account created for The Calgary Guide to Understanding Disease - Linking pathophysiology to clinical presentation - http://calgaryguide.ucalgary.ca/
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pathophysiology symptoms sle erythematosus extraarticular msk ra rheumatoidarthritis systemic alzheimersdisease ankylosingspondylitis comparison criteria degenerative dementia falls gastrointestinal inflammatory jointdisease jointpain
Systemic Lupus Erythematosus (SLE): Musculoskeletal Manifestations • Immune Complex Deposition - Arthralgia, Arthritis
Musculoskeletal Manifestations ... - Arthralgia, Arthritis ... Musculoskeletal #Complications ... pathophysiology #signs ... #symptoms #diagnosis
Systemic Lupus Erythematosus: Gastrointestinal Manifestations - Thrombosis of vessels in the pancreas, Vasculitis -> Acute Pancreatitis
Systemic Lupus Erythematosus ... Gastrointestinal Manifestations ... Gastrointestinal #Complications ... pathophysiology #signs ... #symptoms #diagnosis
Falls: Pathogenesis and Complications Poly-pharmacy Disorders affecting movement and balance - Sensory deficits - Neuromuscular degeneration/Cerebrovascular disease -
Pathogenesis and Complications ... - Parkinson's Disease ... - Arthritis ... Lifestyle #Geriatrics ... #diagnosis
Lupus (SLE): Mucocutaneous Manifestations • Langerhan cells and keratinocytes release cytokines -> localized inflammatory response ->
Manifestations ... Mucocutaneous #Manifestations ... pathophysiology #diagnosis ... #signs #symptoms ... #complications
Primary Sjogren’s Syndrome: Pathogenesis and Clinical Findings • Primary Sjögren's is a solitary process whereas secondary Sjögren's
other autoimmune diseases ... like rheumatoid arthritis ... RA) or systemic lupus ... Pathophysiology #Diagnosis ... #Signs #Symptoms
Alzheimer’s Disease: Pathogenesis and Clinical Findings Risk factor for Late Onset Alzheimer's (99% of cases): - Increasing
Alzheimer’s Disease ... chromosome 21) Signs ... / Symptoms / Complications ... pathophysiology #geriatrics ... #diagnosis #signs
Rheumatoid arthritis (RA): Extra-articular manifestations Skin: • Inflammation of skin (esp. over areas of stress) forms
Rheumatoid arthritis ... Extra-articular manifestations ... interstitial lung disease ... pathophysiology #signs ... #symptoms #diagnosis
Distinguishing between Inflammatory and Degenerative joint disease Inflammatory Joint Disease • Swelling stimulates joint nociceptors -> Pain
Degenerative joint disease ... in Rheumatoid arthritis ... , Lupus, etc) -> ... Extra-articular manifestations ... JointDisease #JointPain #Diagnosis
Kawasaki Disease: Clinical Findings Diagnostic Criteria - Fever and 4/5 of the following: • Conjunctivitis • Polymorphous
Kawasaki Disease ... Clinical Findings Diagnostic ... hands & feet Signs ... /Symptoms/Complications ... : - Coronary Arteritis
Rheumatoid arthritis (RA): Pathogenesis and Joint diseases features • RA affects 1% of population, women >
Rheumatoid arthritis ... Pathogenesis and Joint diseases ... Extra-articular manifestations ... Extra-articular signs ... #symptoms #diagnosis
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