The Calgary Guide to Understanding Disease @TheCalgaryGuide
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Account created for The Calgary Guide to Understanding Disease - Linking pathophysiology to clinical presentation - http://calgaryguide.ucalgary.ca/
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Systemic Lupus Erythematosus (SLE): Musculoskeletal Manifestations

 • Immune Complex Deposition
    - Arthralgia, Arthritis
Systemic Lupus Erythematosus ... - Arthralgia, Arthritis ... Musculoskeletal #Complications ... pathophysiology #signs ... #symptoms #diagnosis
Systemic Lupus Erythematosus: Gastrointestinal Manifestations
 - Thrombosis of vessels in the pancreas, Vasculitis -> Acute Pancreatitis
Systemic Lupus Erythematosus ... #Lupus #Erythematosus ... Gastrointestinal #Complications ... pathophysiology #signs ... #symptoms #diagnosis
Falls: Pathogenesis and Complications
Poly-pharmacy
Disorders affecting movement and balance
 - Sensory deficits
 - Neuromuscular degeneration/Cerebrovascular disease
 -
Pathogenesis and Complications ... - Parkinson's Disease ... - Arthritis ... Lifestyle #Geriatrics ... #diagnosis
Primary Sjogren’s Syndrome: Pathogenesis and Clinical Findings
• Primary Sjögren's is a solitary process whereas secondary Sjögren's
other autoimmune diseases ... arthritis (RA) ... or systemic lupus ... Pathophysiology #Diagnosis ... #Signs #Symptoms
Alzheimer’s Disease: Pathogenesis and Clinical Findings
Risk factor for Late Onset Alzheimer's (99% of cases):
 - Increasing
Alzheimer’s Disease ... chromosome 21) Signs ... / Symptoms / Complications ... pathophysiology #geriatrics ... #diagnosis #signs
Hypersensitivity: Summary
Type I Hypersensitivity:
 • Immunological Mediator: lgE
 • Immunological Target: Allergen Molecules
 • Ex: Antibiotic
Gravis, Graves' Disease ... complexes • Ex: Systemic ... Lupus Erythematosus ... , Reactive Arthritis ... Classification #Diagnosis
Kawasaki Disease: Clinical Findings
Diagnostic Criteria - Fever and 4/5 of the following:
 • Conjunctivitis
 • Polymorphous
Kawasaki Disease ... Clinical Findings Diagnostic ... hands & feet Signs ... /Symptoms/Complications ... : - Coronary Arteritis
Distinguishing between Inflammatory and Degenerative joint disease
Inflammatory Joint Disease
 • Swelling stimulates joint nociceptors -> Pain
Degenerative joint disease ... is oftentimes systemic ... in Rheumatoid arthritis ... , Lupus, etc) -> ... JointDisease #JointPain #Diagnosis
Rheumatoid arthritis (RA): Pathogenesis and Joint diseases features
 • RA affects 1% of population, women >
Rheumatoid arthritis ... Pathogenesis and Joint diseases ... deviation, etc • Systemic ... Extra-articular signs ... #symptoms #diagnosis
Psoriatic Arthritis: Complications

 • Ocular - Inflammation of middle layer of the eye (the uvea, which
Psoriatic Arthritis ... : Complications ... Cardiac - Valvular disease ... pathophysiology #diagnosis ... #signs #symptoms