The Calgary Guide to Understanding Disease @TheCalgaryGuide
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diagnosis signs symptoms allergy erythematosus hypersensitivityreaction orthopedics sle achilles anaphylaxis caudaequina comparison degenerative gastrointestinal inflammatory injury jointdisease jointpain musculoskeletal neurology
Systemic Lupus Erythematosus: Gastrointestinal Manifestations - Thrombosis of vessels in the pancreas, Vasculitis -> Acute Pancreatitis
Systemic Lupus Erythematosus ... Vasculitis -> Acute ... - Budd Chiari Syndrome ... Gastrointestinal #Complications ... #pathophysiology
Systemic Lupus Erythematosus (SLE): Musculoskeletal Manifestations • Immune Complex Deposition - Arthralgia, Arthritis
Systemic Lupus Erythematosus ... #Lupus #Erythematosus ... #SLE #MSK #Musculoskeletal ... #Complications ... #pathophysiology
Type III Hypersensitivity: Pathogenesis and clinical findings Definition: Small antigen-antibody complexes (produced from normal immune response to
the cause: • Systemic ... Lupus • Erythematosus ... HypersensitivityReaction #Allergy #Immunology ... #pathophysiology
Anaphylaxis: Signs and Symptoms Anaphylaxis: when any egg of three conditions is met: 1. Acute onset of skin/mucosal
Acute onset of skin ... symptoms in the acute ... Signs / Symptoms / Complications ... #Anaphylaxis #pathophysiology ... #immunology #diagnosis
Primary Sjogren’s Syndrome: Pathogenesis and Clinical Findings • Primary Sjögren's is a solitary process whereas secondary Sjögren's
Primary Sjogren’s Syndrome ... (PBC), or with systemic ... arthritis (RA) or systemic ... lupus erythematosus ... #Pathophysiology
Acute Spinal Cord Injuries: Pathogenesis and clinical findings • Anterior Cord Syndrome -> Anterior spinal artery
Acute Spinal Cord ... Anterior Cord Syndrome ... weakness and #Acute ... #diagnosis #pathophysiology ... signs #symptoms #msk
Type I Hypersensitivity: Pathogenesis and clinical findings Definition: Production of lgE Antibodies that bind to harmless allergens
Patient's immune system ... cells recruited Complications ... : • Acute Asthma ... HypersensitivityReaction #Allergy #Immunology ... #pathophysiology
Cauda Equina Syndrome Causes: • Large lumbar degenerative disc herniation (central) • Severe lumbar spondylosis • Neoplasm
Cauda Equina Syndrome ... Signs / Symptoms / Complications ... #CaudaEquina #Syndrome ... #MSK #pathophysiology
Achilles Tendon Rupture - Pathogenesis and clinical findings • The Achilles tendon is 15cm long in
warriors") • Acute ... Signs/Symptoms/Complications ... signs #symptoms #pathophysiology ... #msk #orthopedics
Distinguishing between Inflammatory and Degenerative joint disease Inflammatory Joint Disease • Swelling stimulates joint nociceptors -> Pain
is oftentimes systemic ... Rheumatoid arthritis, Lupus ... Comparison #Versus #MSK ... JointPain #Diagnosis #pathophysiology
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