The Calgary Guide to Understanding Disease @TheCalgaryGuide
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Primary Sjogren’s Syndrome: Pathogenesis and Clinical Findings
• Primary Sjögren's is a solitary process whereas secondary Sjögren's
other autoimmune diseases ... like rheumatoid arthritis ... (RA) or systemic ... / Symptoms: - ... #Symptoms
Selective Serotonin Reuptake Inhibitors: Mechanisms and Side Effects
 • Serotonin Syndrome:
   - Autonomic Hyperactivity:
Serotonin Reuptake Inhibitors ... • Serotonin Syndrome ... SSRI Withdrawal Syndrome ... Psychiatry #Diagnosis #Signs ... #Symptoms
Serotonin-Norepinephrine Reuptake Inhibitors(SNRIs): Mechanisms and Side Effects

Withdrawal: Dizziness, Diarrhea, Insomnia, Nausea, Vomiting
Serotonin Syndrome - Potentially Life
Serotonin-Norepinephrine Reuptake Inhibitors ... Vomiting Serotonin Syndrome ... SerotoninNorepinephrine #Inhibitors ... Psychiatry #Diagnosis #Signs ... #Symptoms
Rheumatoid arthritis (RA): Extra-articular manifestations
Skin: 
 • Inflammation of skin (esp. over areas of stress) forms
Rheumatoid arthritis ... (RA): Extra-articular ... interstitial lung disease ... pathophysiology #signs ... #symptoms #diagnosis
Psoriatic Arthritis: Pathogenesis and Clinical findings

In tendons and connective tissues:
 • Enthesitis  - Pain/tenderness over
Psoriatic Arthritis ... Arthritis of DIP ... polyarthritis (like RA ... pathophysiology #diagnosis #signs ... #symptoms
Kawasaki Disease: Clinical Findings
Diagnostic Criteria - Fever and 4/5 of the following:
 • Conjunctivitis
 • Polymorphous
Kawasaki Disease ... Findings Diagnostic Criteria ... hands & feet Signs ... /Symptoms/Complications ... : - Coronary Arteritis
Rheumatoid arthritis (RA): Pathogenesis and Joint diseases features
 • RA affects 1% of population, women >
Rheumatoid arthritis ... and Joint diseases ... Extra-articular signs ... pathophysiology #signs ... #symptoms #diagnosis
Keratoconus: Pathogenesis and Clinical Findings
Genetics
 • Family history of keratoconus
 • Ehlers-Danlos syndrome
 • Down, Turner,
Ehlers-Danlos syndrome ... Turner, Marfan syndromes ... Decr Protease inhibitors ... rubbing • Atopic diseases ... / Symptoms / Complications
Alzheimer’s Disease: Pathogenesis and Clinical Findings
Risk factor for Late Onset Alzheimer's (99% of cases):
 - Increasing
Alzheimer’s Disease ... mutations - Down syndrome ... chromosome 21) Signs ... / Symptoms / Complications ... #symptoms
IgA Vasculitis – Henoch Scholein Purpura: Pathogenesis and Clinical Findings

 - Infectious Agents - 50% have
necrosis factor a inhibitors ... nephrotic/nephritic syndrome ... Arthralgia's (common), arthritis ... Pathophysiology #Diagnosis #Signs ... #Symptoms