The Calgary Guide to Understanding Disease @TheCalgaryGuide
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pathophysiology complications lupus adhesivecapsulitis centralretinalartery cppd crao erythematosus extraarticular frozenshoulder mucocutaneous musculoskeletal occlusion ophthalmology pagetsdisease pseudogout ra rheumatoidarthritis stages staging
Systemic Lupus Erythematosus (SLE): Musculoskeletal Manifestations • Immune Complex Deposition - Arthralgia, Arthritis
Musculoskeletal Manifestations ... Myopathy (Also caused ... #MSK #Musculoskeletal ... pathophysiology #signs ... #symptoms #diagnosis
Pseudogout: pathogenesis and clinical findings - Idiopathic (vast majority of cases) -> Mechanism unknown - Familial
vast majority of cases ... unknown - Familial chondrocalcinosis ... Pseudogout #CPPD #Disease ... #Signs #Symptoms ... Pathophysiology #Diagnosis
Lupus (SLE): Mucocutaneous Manifestations • Langerhan cells and keratinocytes release cytokines -> localized inflammatory response ->
Lupus (SLE): Mucocutaneous ... Manifestations ... hair follicles -> causes ... pathophysiology #diagnosis ... #signs #symptoms
Rheumatoid arthritis (RA): Extra-articular manifestations Skin: • Inflammation of skin (esp. over areas of stress) forms
Extra-articular manifestations ... inflammation tends to cause ... interstitial lung disease ... pathophysiology #signs ... #symptoms #diagnosis
Central Retinal Artery Occlusion: Pathogenesis and clinical findings • Inflammatory Disease: (i.e. GCA, SLE, GPA) ->
• Inflammatory Disease ... GCA, SLE, GPA) - ... retinal edema caused ... ophthalmology #diagnosis ... #signs #symptoms
Adhesive Capsulitis (Frozen Shoulder) - Pathogenesis and Clinical Findings • Primary (Idiopathic): Unknown etiology, but associated
mellitus, thyroid disease ... a stroke that caused ... pathophysiology #diagnosis ... #symptoms #signs ... stages #staging #msk
Paget’s Disease: Complications Abnormal Osteoclasts cause excessive bone turnover -> Incr bone resorption, Incr (abnormal) bone formation MSK
Paget’s Disease: ... Abnormal Osteoclasts cause ... bone formation MSK ... pathophysiology #diagnosis ... #signs #symptoms
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