The Calgary Guide to Understanding Disease @TheCalgaryGuide
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pathophysiology diagnosis signs symptoms menstrualcycle ovariancycle pituitary benign bph feedbackloop genetics gh growthhormone pediatrics peds prostate prostatic uterinecycle 21hydroxylasedeficiency 21ohd
Graves’ Disease: Pathogenesis and Clinical Findings B & T lymphocyte mediated autoimmunity attack TSH receptor -> Continuous
Thyroid gland hyperplasia ... pathophysiology #endocin #endocrinology
Benign Prostatic Hyperplasia: Pathogenesis and Medications Aging -> Increased Testosterone -> Testosterone metabolized into DHT by type
Benign Prostatic Hyperplasia ... cell nuclei -> Hyperplasia ... smooth-muscle hyperplasia ... Benign #Prostatic #Hyperplasia ... #Pharmacology #Urology
21-Hydroxylase Deficiency (21-OHD): Pathogenesis and Clinical Findings Autosomal recessive mutation in CYP21A2 coding for the enzyme 21-OHase
congenital adrenal hyperplasia ... pathophysiology #genetics #endocrinology
Primary Hyperthyroidism - Pathogenesis and Clinical Findings Note: Although rare, gestational diseases can lead to thyrotoxicosis due
Hyperthyroidism #endocrinology
Feedback Loop: Prolactin (PRL) • PRL levels exhibit diurnal, menstrual, and age-related variation • TRH has
#FeedbackLoop #endocrinology
Prader-Willi Syndrome: Pathogenesis and clinical findings • Maternal uniparental disomy: inheriting 2 copies of maternal chromosome
Complications: • Gonadal hypoplasia
Feedback Loop: Growth Hormone (GH) Growth Hormone: • Liver -> GHR activates JAK-STAT pathway -> Incr IGF1
#FeedbackLoop #endocrinology
Menstrual Cycle Physiology: Ovarian Cycle – Brief Overview LH and FSH are required for follicular development and
#menstruation #endocrinology
Growth Hormone Excess - Pathogenesis and clinical findings • Acromegaly and gigantism share the same pathophysiology
signs #symptoms #endocrinology
Erectile Dysfunction: Pathogenesis Erectile Dysfunction - Persistent or recurrent inability to achieve an erection sufficient to achieve
and rigidity Endocrinologic ... Pathophysiology #Urology
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