The Calgary Guide to Understanding Disease @TheCalgaryGuide
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diagnosis sle erythematosus signs symptoms msk allergy comparison degenerative gastrointestinal hypersensitivityreaction immunology jointdisease jointpain lower luti manifestations mucocutaneous musculoskeletal type1
Systemic Lupus Erythematosus: Gastrointestinal Manifestations - Thrombosis of vessels in the pancreas, Vasculitis -> Acute Pancreatitis
Systemic Lupus Erythematosus ... distension #Systemic ... #Lupus #Erythematosus ... Gastrointestinal #Complications ... #pathophysiology
Systemic Lupus Erythematosus (SLE): Musculoskeletal Manifestations • Immune Complex Deposition - Arthralgia, Arthritis
Systemic Lupus Erythematosus ... Osteoporosis #Systemic ... #Lupus #Erythematosus ... Musculoskeletal #Complications ... #pathophysiology
Systemic Lupus Erythematosus (SLE): Pathogenesis • Genetic factors (Mutations in HLA- DR2/HLA-DR3 genes, complement genes, cytokine
Systemic Lupus Erythematosus ... Multiple immune system ... Abnormal release of inflammatory ... #Lupus #Erythematosus ... #SLE #Pathophysiology
Lower Urinary Tract Infections: Complications - Infection damages the urinary tract epithelium causing fibroblast proliferation and
Tract Infections: Complications ... resulting in a systemic ... inflammatory response ... UrinaryTractInfection #LUTI #Pathophysiology ... #Complications
Lupus (SLE): Mucocutaneous Manifestations • Langerhan cells and keratinocytes release cytokines -> localized inflammatory response ->
Lupus (SLE): Mucocutaneous ... cytokines -> localized inflammatory ... Subacute cutaneous lupus ... Manifestations #pathophysiology ... signs #symptoms #complications
Distinguishing between Inflammatory and Degenerative joint disease Inflammatory Joint Disease • Swelling stimulates joint nociceptors -> Pain
Distinguishing between Inflammatory ... joint disease Inflammatory ... is oftentimes systemic ... Rheumatoid arthritis, Lupus ... JointPain #Diagnosis #pathophysiology
Type I Hypersensitivity: Pathogenesis and clinical findings Definition: Production of lgE Antibodies that bind to harmless allergens
Patient's immune system ... release the pro-inflammatory ... secretion • Inflammatory ... cells recruited Complications ... Allergy #Immunology #pathophysiology
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