The Calgary Guide to Understanding Disease @TheCalgaryGuide
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Account created for The Calgary Guide to Understanding Disease - Linking pathophysiology to clinical presentation - http://calgaryguide.ucalgary.ca/
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signs pediatrics growthhormone 21hydroxylasedeficiency 21ohd acute anxiety behavioraldisorder benign bph dysfunction endocin erectile excess feedbackloop genetics glftap glucocorticoids gravesdisease hydrocele
Feedback Loop: Growth Hormone (GH) Growth Hormone: • Liver -> GHR activates JAK-STAT pathway -> Incr IGF1
Growth Hormone (GH ... lipolysis Signs/Symptoms ... #FeedbackLoop #endocrinology ... #pathophysiology ... #pituitary
Growth Hormone Excess - Pathogenesis and clinical findings • Acromegaly and gigantism share the same pathophysiology
share the same pathophysiology ... Overproduction #diagnosis ... #signs #symptoms ... #endocrinology ... #pathophysiology
Pituitary Mass Effects - Pathogenesis and Clinical Findings • Pituitary turnors are almost always a benign
Pituitary Mass Effects ... following order; GH ... Signs / Symptoms ... #SideEffects #endocrinology ... mnemonic #GLFTAP #pathophysiology
Primary Hyperthyroidism - Pathogenesis and Clinical Findings Note: Although rare, gestational diseases can lead to thyrotoxicosis due
production by the pituitary ... Signs/Symptoms: ... Hyperthyroidism #endocrinology ... #pathophysiology
Graves’ Disease: Pathogenesis and Clinical Findings B & T lymphocyte mediated autoimmunity attack TSH receptor -> Continuous
etiology Signs/Symptoms ... GravesDisease #pathophysiology ... #endocin #endocrinology ... #symptoms #signs ... #diagnosis
Glucocorticoid-Induced Osteoporosis: Pathogenesis and Clinical Findings • Negative feedback on hypothalamus/pituitary, Decreasing ACTH -> Decr Sex
on hypothalamus/pituitary ... #Osteoporosis #pathophysiology ... #signs #symptoms ... #diagnosis
21-Hydroxylase Deficiency (21-OHD): Pathogenesis and Clinical Findings Autosomal recessive mutation in CYP21A2 coding for the enzyme 21-OHase
Signs/Symptoms/Complications ... #21HydroxylaseDeficiency #21OHD #pathophysiology ... #genetics #endocrinology ... #peds #pediatrics
Acute Otitis Media: Pathogenesis and Clinical Findings (in Children) Upper Respiratory Tract Infection: - Bacterial: Streptococcus
#OtitisMedia #pathophysiology ... #diagnosis #symptoms ... #signs #peds #pediatrics
Acute Spinal Cord Injuries: Pathogenesis and clinical findings • Anterior Cord Syndrome -> Anterior spinal artery
Injury #Syndromes #diagnosis ... #pathophysiology ... #signs #symptoms ... #orthopedics #neurology
Erectile Dysfunction: Pathogenesis Erectile Dysfunction - Persistent or recurrent inability to achieve an erection sufficient to achieve
and rigidity Endocrinologic ... #Dysfunction #Pathophysiology ... #Urology #Diagnosis
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