The Calgary Guide to Understanding Disease @TheCalgaryGuide
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Account created for The Calgary Guide to Understanding Disease - Linking pathophysiology to clinical presentation - http://calgaryguide.ucalgary.ca/
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diagnosis signs msk orthopedics gh growthhormone pediatrics pituitary 21hydroxylasedeficiency 21ohd acute benign bph childhood differential dislocation feedbackloop femoralhead fractures genetics
Acute Spinal Cord Injuries: Pathogenesis and clinical findings • Anterior Cord Syndrome -> Anterior spinal artery
clinical findings • Anterior ... Cord Syndrome -> Anterior ... Syndromes #diagnosis #pathophysiology ... #signs #symptoms ... #orthopedics #neurology
Growth Hormone Excess - Pathogenesis and clinical findings • Acromegaly and gigantism share the same pathophysiology
Growth Hormone Excess ... share the same pathophysiology ... diagnosis #signs #symptoms ... #endocrinology ... #pathophysiology
Primary Hyperthyroidism - Pathogenesis and Clinical Findings Note: Although rare, gestational diseases can lead to thyrotoxicosis due
thyrotoxicosis due to excess ... hyperthyroidism due to excess ... Signs/Symptoms: ... Hyperthyroidism #endocrinology ... #pathophysiology
Anterior Shoulder Dislocation: Pathogenesis, clinical, and radiographic findings Trauma, Fall on, outstretched arm, Overhead throwing => Abduction
Anterior Shoulder ... joint => Force exceeds ... bone -> Pain #Anterior ... Diagnosis #signs #symptoms ... #orthopedics #pathophysiology
Meralgia paresthetica: Pathogenesis and Clinical Findings Compression/injury of Lateral Femoral Cutaneous Nerve (LFCN) -> Meralgia paresthetica •
Findings Compression/injury ... paresthetica • Symptoms ... 3-6 months of symptom ... ligament (near anterior ... MeralgiaParesthetica #MSK #pathophysiology
Femoral Head Fracture: Pathogenesis and clinical findings • Posterior hip dislocation -> Impaction force from femoral
acetabular wall • Anterior ... femoral head onto anterior ... Avulsion or shearing injury ... msk #diagnosis #pathophysiology ... #signs #symptoms
Feedback Loop: Growth Hormone (GH) Growth Hormone: • Liver -> GHR activates JAK-STAT pathway -> Incr IGF1
lipolysis Signs/Symptoms ... lipid • GH excess ... #FeedbackLoop #endocrinology ... #pathophysiology
21-Hydroxylase Deficiency (21-OHD): Pathogenesis and Clinical Findings Autosomal recessive mutation in CYP21A2 coding for the enzyme 21-OHase
Signs/Symptoms/Complications ... #21HydroxylaseDeficiency #21OHD #pathophysiology ... #genetics #endocrinology ... #peds #pediatrics
Pituitary Mass Effects - Pathogenesis and Clinical Findings • Pituitary turnors are almost always a benign
not always) the anterior ... Signs / Symptoms ... #SideEffects #endocrinology ... mnemonic #GLFTAP #pathophysiology
Varicocele: Pathogenesis and clinical findings Primary: - Anatomically: the left spermatic vein drains into the left renal
retroperitoneal masses - Inferior ... #Varicocele #Pathophysiology ... #Signs #Symptoms ... #Urology #Diagnosis
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