The Calgary Guide to Understanding Disease @TheCalgaryGuide
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Account created for The Calgary Guide to Understanding Disease - Linking pathophysiology to clinical presentation - http://calgaryguide.ucalgary.ca/
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Menstrual Cycle Physiology: The Hypothalamic-Pituitary-Ovarian Axis
Estrogen, when released:
 • Negatively feeds back on the hypothalamus and
The Hypothalamic-Pituitary-Ovarian ... MenstrualCycle #pathophysiology ... #HPOA #HypothalamicPituitary ... #endocrinology ... #feedback
Feedback Loop: Growth Hormone (GH)
Growth Hormone:
 • Liver -> GHR activates JAK-STAT pathway -> Incr IGF1
Feedback Loop: Growth ... metabolic abn #GrowthHormone ... #FeedbackLoop #endocrinology ... #pathophysiology ... #pituitary
Menstrual Cycle Physiology: Ovarian Cycle – Ovulation Explained

Around Day 14, estrogen exerts sudden +++ positive feedback
sudden +++ positive feedback ... on the anterior pituitary ... negative to positive feedback ... #OvarianCycle #pathophysiology ... #Ovulation #endocrinology
Feedback Loop: Prolactin (PRL)
 • PRL levels exhibit diurnal, menstrual, and age-related variation
 • TRH has
Feedback Loop: Prolactin ... #FeedbackLoop #endocrinology ... #pathophysiology ... #pituitary
Growth Hormone Excess - Pathogenesis and clinical findings
 • Acromegaly and gigantism share the same pathophysiology
share the same pathophysiology ... Carpal Tunnel Syndrome ... fraction • HTN #GrowthHormone ... signs #symptoms #endocrinology ... #pathophysiology
Menstrual Cycle Physiology: Ovarian Cycle – Follicular Phase Explained
Early Follicular Phase (Days 0-5)
 • Granulosa cells
production by pituitary ... back on anterior pituitary ... Polycystic Ovarian Syndrome ... #OvarianCycle #pathophysiology ... FollicularPhase #endocrinology