The Calgary Guide to Understanding Disease @TheCalgaryGuide
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pathophysiology signs symptoms allergy sle hypersensitivityreaction immunology classification definitions gastrointestinal hypersensitivity manifestations msk mucocutaneous musculoskeletal primary sjogrens syndrome type1 type3
Hypersensitivity: Summary Type I Hypersensitivity: • Immunological Mediator: lgE • Immunological Target: Allergen Molecules • Ex: Antibiotic
complexes • Ex: Systemic ... Lupus Erythematosus ... Dermatitis (ie. reaction ... #Allergic #Reactions ... Classification #Diagnosis
Systemic Lupus Erythematosus: Gastrointestinal Manifestations - Thrombosis of vessels in the pancreas, Vasculitis -> Acute Pancreatitis
Systemic Lupus Erythematosus ... the pancreas, Vasculitis ... #Lupus #Erythematosus ... Gastrointestinal #Complications ... signs #symptoms #diagnosis
Type I Hypersensitivity: Pathogenesis and clinical findings Definition: Production of lgE Antibodies that bind to harmless allergens
leading to an allergic ... reaction. ... Sensitization" to Allergen ... Patient's immune system ... cells recruited Complications
Systemic Lupus Erythematosus (SLE): Musculoskeletal Manifestations • Immune Complex Deposition - Arthralgia, Arthritis
Systemic Lupus Erythematosus ... Osteoporosis #Systemic ... #Lupus #Erythematosus ... Musculoskeletal #Complications ... signs #symptoms #diagnosis
Type III Hypersensitivity: Pathogenesis and clinical findings Definition: Small antigen-antibody complexes (produced from normal immune response to
the cause: • Systemic ... Lupus • Erythematosus ... HypersensitivityReaction #Allergy
Primary Sjogren’s Syndrome: Pathogenesis and Clinical Findings • Primary Sjögren's is a solitary process whereas secondary Sjögren's
(PBC), or with systemic ... arthritis (RA) or systemic ... lupus erythematosus ... Pathophysiology #Diagnosis
Lupus (SLE): Mucocutaneous Manifestations • Langerhan cells and keratinocytes release cytokines -> localized inflammatory response ->
Lupus (SLE): Mucocutaneous ... Subacute cutaneous lupus ... Livedo Reticularis, Vasculitis ... pathophysiology #diagnosis ... signs #symptoms #complications
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