The Calgary Guide to Understanding Disease @TheCalgaryGuide
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diagnosis signs sle symptoms allergy hypersensitivityreaction immunology classification gastrointestinal hypersensitivity manifestations msk mucocutaneous musculoskeletal primary reactions sjogrens syndrome type1 type3
Systemic Lupus Erythematosus: Gastrointestinal Manifestations - Thrombosis of vessels in the pancreas, Vasculitis -> Acute Pancreatitis
Systemic Lupus Erythematosus ... the pancreas, Vasculitis ... #Lupus #Erythematosus ... Gastrointestinal #Complications ... #pathophysiology
Hypersensitivity: Summary Type I Hypersensitivity: • Immunological Mediator: lgE • Immunological Target: Allergen Molecules • Ex: Antibiotic
Immunological Target: Allergen ... Ex: Antibiotic allergies ... complexes • Ex: Systemic ... Lupus Erythematosus ... Classification #Diagnosis #Definitions
Type I Hypersensitivity: Pathogenesis and clinical findings Definition: Production of lgE Antibodies that bind to harmless allergens
clinical findings Definition ... leading to an allergic ... Patient's immune system ... cells recruited Complications ... #Immunology #pathophysiology
Type III Hypersensitivity: Pathogenesis and clinical findings Definition: Small antigen-antibody complexes (produced from normal immune response to
clinical findings Definition ... the cause: • Systemic ... Lupus • Erythematosus ... HypersensitivityReaction #Allergy ... #Immunology #pathophysiology
Systemic Lupus Erythematosus (SLE): Musculoskeletal Manifestations • Immune Complex Deposition - Arthralgia, Arthritis
Systemic Lupus Erythematosus ... Osteoporosis #Systemic ... #Lupus #Erythematosus ... Musculoskeletal #Complications ... #pathophysiology
Systemic Lupus Erythematosus (SLE): Pathogenesis • Genetic factors (Mutations in HLA- DR2/HLA-DR3 genes, complement genes, cytokine
Systemic Lupus Erythematosus ... Multiple immune system ... IL-6, IL-10 #Systemic ... #Lupus #Erythematosus ... #SLE #Pathophysiology
Primary Sjogren’s Syndrome: Pathogenesis and Clinical Findings • Primary Sjögren's is a solitary process whereas secondary Sjögren's
(PBC), or with systemic ... arthritis (RA) or systemic ... lupus erythematosus ... Sjogrens #Syndrome #Pathophysiology
Lupus (SLE): Mucocutaneous Manifestations • Langerhan cells and keratinocytes release cytokines -> localized inflammatory response ->
Lupus (SLE): Mucocutaneous ... Subacute cutaneous lupus ... Livedo Reticularis, Vasculitis ... Manifestations #pathophysiology ... signs #symptoms #complications
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