Causes of Anemia by Mean Corpuscular Volume (MCV) - Differential Diagnosis Algorithm Low Mean Corpuscular Volume (<80 fL) • Iron Deficiency • Thalassemia • Lead Poisoning • Anemia of Chronic Disease Normal Mean Corpuscular Volume (80-100 fL) • Bleeding • Hemolysis • Marrow Failure • Anemia of Chronic Disease (e.g. Renal Disease, Liver Disease, Endocrinopathy, Chronic Inflammation, Chronic Infection) High Mean Corpuscular Volume (>100 fL) • B12 Deficiency • Folate Deficiency • Drugs • Reticulocytosis • Liver Disease • Hypothyroidism • Myelodysplasia #Anemia #MCV #Classification #Differential #Diagnosis #Algorithm #Causes #Hematology

Lymphomas and Lymphoproliferative Disorders - Differential Diagnosis Algorithm Hodgkin Lymphoma ~40% - Characteristic For Reed-Sternberg (RS) Cells - usually at a single site in lymphatic system (node) with progression contiguously with lymphatic system. - Bimodal Age Distribution - better prognosis • Nodular Lymphocyte - 5% RS cells absent, lymphocyte predominant (LP) tumour B cells are present • Classic - Nodular Sclerosis, Mixed Cellularity, Lymphocyte Rich, Lymphocyte Depletion Non-Hodgkin lymphomas (NHL) ~60% - lymphadenopathy more diffuse, can have extra nodal involvement, irregular pattern of spread, B symptoms not as common - T Cell ~10% - B-Cell ~90% • Low Grade - Slow growing, Poorly Responsive to Treatment • Aggressive/ Intermediate - Faster growing Potential For Cure, Most common, Wide age range • High Grade - Very Lethal if untreated, Behave and Treated Like Acute Leukemias, very high mitotic rate correlated with rapid growth, response to treatment and relapse - Amy Chung, MD, MSc @AmyChung #Lymphomas #Lymphoproliferative #Disorders #Classification #pathophysiology #Hematology #Diagnosis #NonHodgkin #differential #algorithm