30 results
Diagnosis and Management of Idiosyncratic Drug-induced Liver Injury (DILI)

DILI Types:
 • Intrinsic - predictable, dose dependent
presentation • Chronic ... - ongoing ↑ LFTs ... disease 6-9 mo ... #differential # ... gastroenterology #algorithm
Hepatocellular Liver Injury - Differential Diagnosis Framework:
Liver Injury → liver test abnormalities without evidence of liver
Injury - Differential ... Injuryliver ... phosphatase) 2) ... Injury Differential ... #Injury #Differential
Patterns of Liver Injury
Transaminase Levels:
  > 50x normal - Ischemic Hepatitis
  > 20x normal
5-10x normal - Chronic ... Skeletal muscle 2- ... #Injury #hepatology ... #LFTs #transaminitis ... #differential #
Acute-on-Chronic Liver Failure (ACLF) Clinical Guidelines

ACLF = possibly reversible condition in those with CLD (± cirrhosis)
ACLF) Clinical Guidelines ... months without treatment ... disease, liver ... Injury (DILI) ... #Cirrhosis #Hepatology
Liver Chemistries - Interpretation of LFTs

R-value: Serum (ALT/ULN ALT) / (Alk phos/ULN ALP)
 • R >
Interpretation of LFTs ... disease: > 2 ... • NASH, Chronic ... chemistry #diagnosis #differential ... #Hepatology #transaminitis
Acute Liver Injury - Differential Diagnosis Algorithm

Vascular Causes of Acute Liver Injury: 
 • Hepatic vein:
Acute Liver Injury ... - Differential ... Diagnosis Algorithm ... disease: > 2 ... #hepatology
Drug Induced Liver Injury (DILI) - Stepwise Diagnosis Algorithm
DILI suspicion
Features toxic aetiology: Skin involvement, Kidney injury,
Stepwise Diagnosis Algorithm ... non-essential drug/HDS treatments ... disease, Hepatic ... e.g. ascites), Chronic ... #Algorithm #hepatology
Shock - Differential Diagnosis Framework
 - MAP <65. SBP <90, drop in SBP > 40
 -
Insufficiency, Liver ... , Severe Valve Disease ... ) MAP > 60-65 2) ... #criticalcare #algorithm ... #treatment #management
Abnormal liver function tests algorithm.
 This figure details the initial response to abnormal liver blood tests.
tests algorithm ... type 2 diabetes ... #LFTs #Abnormal ... #Algorithm #Hepatology ... #Differential #
Autoimmune Hepatitis

Clinical Presentation
 - Highly variable clinical presentation, from subclinical disease to acute liver failure.
 -
from subclinical disease ... - Symptoms of chronic ... injury, though ... regarding need for treatment ... #Hepatology