18 results
Systemic Sclerosis (Scleroderma)
Multi-system autoimmune disease characterized by vasculopathy and progressive fibrosis of skin and internal organs
3
Systemic Sclerosis ... autoimmune disease ... internal organs 3 ... and Symptoms: ... #SSc #rheumatology
Multiple Sclerosis - Summary

Multiple Sclerosis (MS) is an autoimmune-mediated neurodegenerative disease of the central nervous system
neurodegenerative disease ... central nervous system ... Signs and symptoms ... McDonald diagnostic criteria ... ) • Acute:
Primary Biliary Cirrhosis - Diagnosis Algorithm
Symptoms: Fatigue, Pruritus, Right upper quadrant discomfort
Signs: Jaundice, Xanthelasmata, Hepatomegaly
Associated history:
quadrant discomfort Signs ... criteria are met ... Elevated ALP 2. ... gp210/sp100) 3. ... Diagnosis #Algorithm #hepatology
Systemic Lupus Erythematosus - Diagnosis
Manifestations:
 - Arthritis 69%
 - Malar rash 40%
 - Fever 36%
 -
Lung involvement 3% ... malignancies, Multiple sclerosis ... autoantibodies #signs ... #symptoms #mimickers ... #differential #rheumatology
Amyotrophic Lateral Sclerosis (ALS) Summary
ALS: combination of the clinical examination finding of amyotrophy with the pathologic
of the nervous system ... Presentation: - Disease ... course of the disease ... fasciculations Common Symptoms ... more regions 3.
Lymphomas and Lymphoproliferative Disorders - Differential Diagnosis Algorithm
Hodgkin Lymphoma ~40% - Characteristic For Reed-Sternberg (RS) Cells
Classic - Nodular Sclerosis ... pattern of spread, B symptoms ... not as common ... Treated Like Acute ... pathophysiology #Hematology
Diagnostic Criteria for Sweet Syndrome (Acute Febrile Neutrophilic Dermatosis)
Major criteria 
 1. Abrupt onset of tender
Sweet Syndrome (Acute ... inflammatory disease ... treatment with systemic ... Sweet #Syndrome #Acute ... #Diagnosis #Hematology
Vasculitis and Vasculitides - Differential Diagnosis Framework

When to Consider Vasculitis:
 • Purpura, ischemic skin lesions
 •
, such as systemic ... Symptoms (Sx) in ... , particularly scleritis ... purpura: strong sign ... differential #diagnosis #rheumatology
Polycythemia Vera (PV) - Diagnosis and Management Summary
Diagnostic Criteria:
 • Elevated hemoglobin and/or hematocrit AND
 •
Summary Diagnostic Criteria ... When present, symptoms ... , signs, and complications ... von Willebrand disease ... Summary #treatment #hematology
Hemophagocytic Lymphohistiocytosis (HLH)
Definition: Overwhelming clinical syndrome associated with excessive macrophage activation and cytokine storm due to
affects infants < 3 ... is also observed ... and symptoms can ... acute or subacute ... management #treatment #hematology