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differential rheumatology algorithm classification diseases acute aki ana antibody antineutrophil antinuclear arterial associations autoantibodies bloodsmear borrelia clinical cryoglobulinemia cryoglobulins embolism
ANA (Antinuclear Antibody) and ANCA (Antineutrophil cytoplasmic antibodies) • Systemic lupus erythematosus 1. Anti-dsDNA
Antineutrophil cytoplasmic antibodies ... • Sjögren syndrome ... Vasculitis: • ... Microscopic polyangiitis ... #diagnosis #rheumatology
Autoantibodies and their Disease Associations ANA - Non-specific; common in SLE, autoimmune hepatitis Anti-CCP, Rheumatoid factor - RA Anti-dsDNA
- Vasculitis, e.g ... - Vasculitis, e.g ... Microscopic polyangiitis ... Associations #diseases #diagnosis ... #rheumatology #antibodies
Vasculitis and Vasculitides - Differential Diagnosis Framework When to Consider Vasculitis: • Purpura, ischemic skin lesions •
- Differential Diagnosis ... ): • Microscopic ... tract, and often causes ... Dx: GPA, EGPA, microscopic ... ) pattern: antibodies
Rapidly Progressive Glomerulonephritis (RPGN) RPGN has three primary pathophysiologic causes differentiated by immunofluorescence Immune Complex Mediated (granular staining):
three primary pathophysiologic ... causes differentiated ... Purpura Anti-GBM antibodies ... Glomerulonephritis #Vasculitis ... #differential #diagnosis
Acute Kidney Injury - AKI Workup Algorithm and Differential Diagnosis Baseline Investigations: full blood count with differential,
and Differential Diagnosis ... dipstick, urine microscopy ... osmolarity If cause ... Glomerulonephritis / Vasculits ... : ANCA, ANA, Anti-GBM
Vasculitis - Differential Diagnosis Framework When to Consider Vasculitis: • Purpura, ischemic skin lesions • Mononeuritis multiplex • Hematuria, proteinuria,
Diagnosis Framework ... Differential Diagnosis ... )): Microscopic ... tract, and often causes ... • Cogan syndrome
Pulmonary Renal Syndromes - OnePager Summary Autoimmune ANCA vasculitis (AAV): GPA (granulomatous with polyangiitis), EGPA (eosinophilic granulomatosis
Summary Autoimmune ANCA ... vasculitis (AAV ... EGPA) • Auto-antibodies ... : ANCA antibody, ... Goodpasture's cause
Cryoglobulinemia Summary Cryoglobulins: • Cryoglobulins are Igs in the serum that precipitate in vitro at temperatures below
• They can cause ... Cryoglobulins Cause ... Labs/Diagnosis: ... DDX: • ANCA (Antineutrophil ... - GPA, EGPA, microscopic
Venous Thrombosis vs Arterial Thrombosis - Differential Diagnosis Framework VENOUS THROMBOSIS • Acquired Risk Factors: - >48 hours
- Differential Diagnosis ... • Nephrotic Syndrome ... Antiphospholipid antibodies ... 19 - PNH - Vasculitis ... Venous #Arterial #pathophysiology
Borrelia recurrentis on Peripheral Blood Smear 23M Somali refugee recently arrived w/severe abd pain, confusion and fever
resolved after 2-3d ... Syndrome: 3d of ... LBRF can be diagnosed ... and convalescent antibodies ... recurrentis #BloodSmear #microscopy
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