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diagnosis differential nephrology urine renal rheumatology acute management nephrotic proteinuria pulmonary syndromes urology vasculitis aki ana anca antibodies antibody antineutrophil
Algorithmic Approach to Acute Interstitial Nephritis When to suspect AIN? (not sensitive) • AKI, AKD, rapidly progressive
sterile pyuria, WBC casts ... eosinophiluria, microscopic ... hematuria, mild ... tubular proteinuria, granular ... casts/RTE; blend
Hematuria - Differential Diagnosis Framework Gross Hematuria: Red/Dark urine • 1ml blood/liter urine can induce color change
urine sediment Microscopic ... urine sediment by microscopy ... hematuria syndrome ... : - RBC casts ... microscopic and
Urine Microscopy - Casts Acellular Casts • Hyaline Casts - Consists of only precipitated Tamm-Horsfell protein without
Urine Microscopy ... but can be seen in ... suggestive of nephrotic sydnrome ... ) • Granular Casts ... #Urine #Microscopy
Causes of Hematuria - Differential Diagnosis Algorithm Red blood cells on urine microscopy. Must exclude false positives
Causes of Hematuria ... cells on urine microscopy ... RBCs and/or RBC casts ... with polyangiitis/microscopic ... #Causes
Atlas of Urine Microscopy Findings • Epithelial cells - Normal • Renal tubular cells - Acute
• Red cell casts ... • White cell casts ... infection • Hyaline casts ... renal disease • Granular ... casts - More significant
Urinary Casts and Disease Associations Hyaline - May be nonspecific; seen in normal individuals or during severe
Urinary Casts and ... breakdown of cellular casts ... casts are seen ... 34t5DgJ #Urinary #Casts ... #Differential #Microscopy
Causes of Dysuria - Differential Diagnosis Algorithm Pyuria - Leukocytes on Dipstick/Microscopy - Bacteriuria & Hematuria -
Leukocytes on Dipstick/Microscopy ... Bacteriuria & Hematuria ... Pyelonephritis - WBC Casts ... Leukocytes on Dipstick/Microscopy ... #Causes
Nephritic vs Nephrotic Syndrome Step 1: If the patient has hematuria and/or proteinuria, think about nephrotic/nephritic syndromes. Step
the patient has hematuria ... have glomerular hematuria ... (RBC casts or dysmorphic ... RBCs in urine)? ... #Comparison #Algorithm
Causes of Acute Kidney Injury (AKI) - Differential Diagnosis Algorithm Acute Kidney Injury (AKI) - Acute increase
Acute increase in ... • Hepatorenal syndromes ... Epithelial cell casts ... polyangiitis /microscopic ... #Causes
Causes of Proteinuria - Differential Diagnosis Algorithm Persistent Proteinuria >150mg/d protein present on repeat testing including overnight
Differential Diagnosis Algorithm ... • Fanconi's syndrome ... sediment - WBC/RBC casts ... polyangiitis (GPA) / microscopic ... Differential #Diagnosis #Algorithm
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