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diagnosis differential anca antibodies causes classification diseases nephrology acute aki algorithm antineutrophil antinuclear associated associations autoantibodies blood canca cryoglobulinemia cryoglobulins
ANA (Antinuclear Antibody) and ANCA (Antineutrophil cytoplasmic antibodies) • Systemic lupus erythematosus 1. Anti-dsDNA
ANA (Antinuclear ... Antibody) and ANCA ... • Sjögren syndrome ... Microscopic polyangiitis ... antibodies #diagnosis #rheumatology
ANCA-Associated Vasculitis A group of necrotizing, small-vessel vasculitis without immune complex deposition. Complement levels are normal due
polyangiitis (GPA), microscopic ... associated with PR3+ antibody ... polyangiitis without renal ... involvement - PR3>MPO Microscopic ... PR3 #Diagnosis #Rheumatology
Hematuria - Differential Diagnosis Framework Gross Hematuria: Red/Dark urine • 1ml blood/liter urine can induce color change
urine sediment Microscopic ... urine sediment by microscopy ... hematuria: - RBC casts ... Diagnostic of GN or vasculitis ... Diagnosis #causes #urology
Autoantibodies and their Disease Associations ANA - Non-specific; common in SLE, autoimmune hepatitis Anti-CCP, Rheumatoid factor - RA Anti-dsDNA
Disease Associations ANA ... - Vasculitis, e.g ... Microscopic polyangiitis ... U1-RNP antibody ... diagnosis #table #rheumatology
Pulmonary Renal Syndromes - OnePager Summary Autoimmune ANCA vasculitis (AAV): GPA (granulomatous with polyangiitis), EGPA (eosinophilic granulomatosis
vasculitis (AAV ... polyangiitis), MPA (microscopic ... antibody • Urine ... FINDINGS: • U/A: microscopic ... hematuria, RBC casts
Acute Kidney Injury - AKI Workup Algorithm and Differential Diagnosis Baseline Investigations: full blood count with differential,
dipstick, urine microscopy ... Glomerulonephritis / Vasculits ... , HIV serology, ... Abdominal compartment syndrome ... syndrome: troponin
Vasculitis and Vasculitides - Differential Diagnosis Framework When to Consider Vasculitis: • Purpura, ischemic skin lesions •
renal abnormalities ... ): • Microscopic ... Dx: GPA, EGPA, microscopic ... (Renal involvement ... differential #diagnosis #rheumatology
Cryoglobulinemia Summary Cryoglobulins: • Cryoglobulins are Igs in the serum that precipitate in vitro at temperatures below
Hyperviscosity Syndrome ... 20% Sjögren's syndrome ... cytoplasmic antibody ... - GPA, EGPA, microscopic ... classification #rheumatology
Vasculitis - Differential Diagnosis Framework When to Consider Vasculitis: • Purpura, ischemic skin lesions • Mononeuritis multiplex • Hematuria, proteinuria,
renal abnormalities ... )): Microscopic ... • Behcet syndrome ... • Cogan syndrome ... Differential #Diagnosis #Rheumatology
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