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Overall Approach to Anemia - Differential Diagnosis Algorithm Blood Loss • Acute Bleed - Normocytic / Normochromic
- Differential Diagnosis ... Deficiency • Aplastic ... of Chronic Disease ... #Differential #Diagnosis ... Algorithm #Causes #Hematology
Aplastic Anemia Summary • Definition • Pathophysiology • DDx: AA vs Hypocellular MDS • Expectation •
Aplastic Anemia ... vs Hypocellular MDS ... @ZhuoerXie #Aplastic ... #Anemia #diagnosis ... #oncology #hematololgy
Causes of Anemia with Normal Mean Corpuscular Volume (MCV) - Differential Diagnosis Algorithm Decreased WBCs - Decreased/NormaI
Causes of Anemia ... - Differential Diagnosis ... • Marrow Aplasia ... #Differential #Diagnosis ... Algorithm #Causes #Hematology
Algorithmic Approach to Anemia - Differential Diagnosis Framework by MCV Microcytic (MCV < 80) "TAILS": • Thalassemia
- Differential Diagnosis ... Non-hemolytic: ACD, Aplastic ... Non-megaloblastic: Liver disease ... Reticulocytosis, MDS ... #hematology
Aplastic Anemia - Illness Script Signs and symptoms: • Recurrent infections from neutropenia • Mucosal bleeding from
Aplastic Anemia ... Illness Script Signs ... Can progress to MDS ... #Anemia #diagnosis ... management #treatment #hematology
Red Blood Cell (RBC) Morphology Microcytic RBC: Pyridoxine deficiency, Thalassemia, Iron deficiency anemia, Chronic disease anemia (sometimes),
Iron deficiency anemia ... , MDS, Chemotherapy ... iron deficiency anemia ... #differential #diagnosis ... #hematology #microscopy
Common RBC Inclusions and Associations • Howell Jolly Bodies: Hyposplenism, Asplenism, Severe hemolytic anemia • Heinz
Common RBC Inclusions ... : Hemoglobin H disease ... , Sickle cell, MDS ... #Bodies #diagnosis ... #hematology
Hemolytic Anemias - Differential Diagnosis Algorithm Signs of anemia and hemolysis: • ↓ Haptoglobin • ↑ LDH
- Differential Diagnosis ... Algorithm Signs ... • Extrinsic RBC ... • Intrinsic RBC ... #Algorithm #hematology
Aplastic Anemia - Overview Who? • M = F • 3 peaks: 1) Childhood 2) 15-25 years 3) >60 years What? • Aplastic anemia
Aplastic Anemia ... • Aplastic anemia ... Pancytopenia: • ↓ RBC ... • ↓ WBC • ↓ ... #hematology #diagnosis
Approach to Hypoproliferative Macrocytic Anemia • 812, Folate Deficiency • MDS+ • Hypothyroid • Liver Disease
Deficiency • MDS ... Hypothyroid • Liver Disease ... #Macrocytic #Anemia ... #differential #diagnosis ... #algorithm #hematology
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