23 results
Hemolytic Anemias - Differential Diagnosis Algorithm

Signs of anemia and hemolysis:
 • ↓ Haptoglobin
 • ↑ LDH
Diagnosis Algorithm Signs ... • Extrinsic RBC ... • Intrinsic RBC ... Matthew Ho, MD ... Diagnosis #Algorithm #hematology
Common RBC Inclusions and Associations
 • Howell Jolly Bodies: Hyposplenism, Asplenism, Severe hemolytic anemia
 • Heinz
Common RBC Inclusions ... , Hemolytic anemia ... , Sickle cell, MDS ... #RBC #Inclusions ... Bodies #diagnosis #hematology
Red Blood Cell (RBC) Morphology
Microcytic RBC: Pyridoxine deficiency, Thalassemia, Iron deficiency anemia, Chronic disease anemia (sometimes),
Liver Disease, MDS ... iron deficiency anemia ... Autoimmune hemolytic anemia ... autoimmune hemolytic anemia ... differential #diagnosis #hematology
Aplastic Anemia - Overview

Who?
• M = F
• 3 peaks:	1) Childhood	2) 15-25 years	3) >60 years

What?
• Aplastic anemia
(MDS) (normal or ... Hypocellular/Hypoplastic MDS ... abnormalities typical for MDS ... Pancytopenia: • ↓ RBC ... Treatment:
Aplastic Anemia - Illness Script
Signs and symptoms:
 • Recurrent infections from neutropenia
 • Mucosal bleeding from
Illness Script Signs ... Treatment: • Consider ... Can progress to MDS ... diagnosis #management #treatment ... #hematology
Algorithmic Approach to Anemia - Differential Diagnosis Framework by MCV

Microcytic (MCV < 80) "TAILS":
 • Thalassemia
Algorithmic Approach to Anemia ... Spherocytosis, G6PD, PK, HbC ... Reticulocytosis, MDS ... Matthew Ho, MD ... Differential #Diagnosis #hematology
Myelodysplastic Syndrome (MD) - Diagnosis and Management Summary
myelo (marrow) -dys- (abnormal) -plastic (shape) = funny-shaped cells
Myelodysplastic Syndrome ... cytopenias (usually anemia ... #MDS #Diagnosis ... #Management #treatment ... #hematology #oncology
VEXAS (Vacuoles, E1 enzyme, X-linked, Autoinflammatory, Somatic) Syndrome
Clinical Syndrome:
 • Common Clinical Features: alveolitis, ear and
Abnormalities: macrocytic anemia ... (MDS) Most met ... (MDS) and/or ... Maheswaranathan, MD ... Autoinflammatory #Somatic #rheumatology
Pancytopenia - Workup and Differential Diagnosis Algorithm
Consumption Disorders
 1. Autoimmune Mediated Pancytopenia
 2. Splenic Sequestration
Peripheral Destruction
HLH syndrome 5. ... Acquired Aplastic Anemia ... • Hypoplastic MDS ... marrow failure syndrome ... Diagnosis #Algorithm #Hematology
Myelodysplastic Syndromes (MDS)

What?
Myelodysplastic syndromes are a group of disorders caused by blood cells that are poorly
(MDS) What? ... platelets) • MDS ... precursors MDS ... chemotherapy #MDS ... #diagnosis #hematology