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diagnosis hematology differential oncology causes management chronic cll erythematosus hemeonc lupus lymphocytic signs sle systemic workup anorexianervosa aplastic auer auerrods
Leukemias Overview: ALL, CML, AML, APML, CLL Acute leukemias > 20% blasts in the peripheral blood smear
rapid onset of symptoms ... Symptoms: • Malaise ... - infiltrates (anemia ... , thrombocytopenia ... #Hematology #Oncology
Causes of Thrombocytopenia - Differential Diagnosis Algorithm Decreased Megakaryopoiesis • Aplastic Anemia • Toxic Damage (e.g.
Causes of Thrombocytopenia ... Megakaryopoiesis • Aplastic Anemia ... Leukemia, Tumour ... SLE • CLL • APLA ... #Causes #Hematology
A 37-year-old woman initially presented with pancytopenia and found to have leukopenia (2.1 × 103/μL) with
promyelocytes, anemia ... 6.8 g/dL), and thrombocytopenia ... bilobed nuclei, fine ... promyelocytic leukemia ... In addition to APL
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 Causes of Thrombocytosis - Differential Diagnosis Algorithm Spurious: • Artifact (redo CBC) Autonomous: • Essential thrombocytosis • Polycythemia
Differential Diagnosis Algorithm ... Chronic Myelogenous Leukemia ... following EtOH induced thrombocytopenia ... Iron deficiency anemia ... #Causes #Hematology
Approach to Leukocytosis - Differential Diagnosis Algorithm Features of hematologic malignancy: • Symptoms: B-symptoms, bruising/bleeding, fatigue/weakness, immunosuppression
malignancy: • Symptoms ... : B-symptoms, bruising ... hepatomegaly • Labs: anemia ... #hematology #WBC ... #Leukemoid
Chronic Lymphocytic Leukemia (CLL) - Summary Overview: • Most common leukemia in adults • Disorder of
• Most common leukemia ... of anemia or thrombocytopenia ... marrow failure with anemia ... or thrombocytopenia ... #oncology #hematology
Chronic Lymphocytic Leukemia - Summary Cancer affecting lymphocytes/Mature B cell neoplasm • Lymphocytes accumulate in large numbers
Chronic Lymphocytic Leukemia ... with no early symptoms ... • Neutropenia, anemia ... , thrombocytopenia ... workup #oncology #hematology
Systemic Lupus Erythematosus - Diagnosis Manifestations: - Arthritis 69% - Malar rash 40% - Fever 36% -
Neurological 12% - Thrombocytopenia ... - Hemolytic anemia ... - Anti-B2GP1 (aPL ... autoantibodies #signs #symptoms ... #differential #rheumatology
Causes of Thrombocytopenia and Platelet Disorders - Differential Diagnosis and Workup History: - Prior platelet count, family
Causes of Thrombocytopenia ... pylori test (GI symptoms ... changes), high MCV anemia ... not required in all ... Causes #Workup #hematology
Aplastic Anemia - Overview Who? • M = F • 3 peaks: 1) Childhood 2) 15-25 years 3) >60 years What? • Aplastic anemia
Aplastic Anemia ... infections/fevers • Thrombocytopenia ... virus (EBV) • Leukemia ... • Improve the symptoms ... #oncology #hematology
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