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hematology differential management workup causes hemolytic leukemia chronic lymphocytic mds monoclonal myelodysplastic agglutinin arteritis calculation classification cold common cvid disease
Hemolysis - Diagnostic Algorithm and Causes Increased red cell production: • Increased Reticulocytosis/polychromasia • Erythroid
Hemolysis - Diagnostic ... Algorithm and Causes ... Increased red cell ... Increased red cell ... #Hemolytic #Anemia
Chronic Lymphocytic Leukemia - Summary Cancer affecting lymphocytes/Mature B cell neoplasm • Lymphocytes accumulate in large numbers
Leukemia - Summary Cancer ... • Neutropenia, anemia ... microglobulin Treatment ... #workup #oncology ... #hematology
Causes of Anemia with Normal Mean Corpuscular Volume (MCV) - Differential Diagnosis Algorithm Decreased WBCs - Decreased/NormaI
- Differential Diagnosis ... Algorithm Decreased ... , Target Cells ... Inflammation • Cancer ... #Hematology
Leukemias Overview: ALL, CML, AML, APML, CLL Acute leukemias > 20% blasts in the peripheral blood smear
- infiltrates (anemia ... Phosphorus CLL ... lymphoid organs When Cancer ... ) CLL Symptoms: ... #Oncology #Diagnosis
Causes of Extravascular and Intravascular Hemolysis - Differential Diagnosis Algorithm Extravascular - Spleen and RES-mediated hemolysis -
- Differential Diagnosis ... Algorithm Extravascular ... • Sickle cell ... anemia • ... #Hematology
Cold Agglutinin Disease 3 Types of Cold Sensitive Antibodies: 1. Cold Agglutinins (CAD) 2. Donath-Landsteiner
lymphoid malignancy (CLL ... Diagnosis: • hemolytic ... malignancies - B-cell ... malignancies -> CLL ... #anemia #hematology
Hemolytic Anemia - Differential Diagnosis Algorithm • Sickle cells - Consider sickle cell disease (diverse genotypes):
Hemolytic Anemia ... Algorithm • Sickle ... cells - Consider ... sickle cell disease ... #Diagnosis #Algorithm
Myelodysplastic Syndrome (MD) - Diagnosis and Management Summary myelo (marrow) -dys- (abnormal) -plastic (shape) = funny-shaped cells
= funny-shaped cells ... cytopenias (usually anemia ... Allogeneic stem cell ... #Management #treatment ... #hematology #oncology
Reticulocyte Production Index = (Retic %) x (Hct / 45) / Maturation Factor The maturation factor is
infiltration (e.g. cancer ... Microangiopathic hemolytic ... defects (e.g. sickle cell ... Production #Index #hematology ... #diagnosis #calculation
Anemia Diagnostic Algorithm Mean corpuscular (cell) volume (MCV): Average RBC size. Under 80 = microcytic. Between 80-95
Anemia Diagnostic ... corpuscular (cell ... Red cell distribution ... acute blood loss, hemolysis ... #Algorithm #Diagnosis
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